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Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs  Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich.

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Presentation on theme: "Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs  Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich."— Presentation transcript:

1 Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs 
Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich A Stock, MD, Mitsugi Nagashima, MD, John E Mayer, MD  The Annals of Thoracic Surgery  Volume 75, Issue 1, Pages (January 2003) DOI: /S (02)

2 Fig 1 (A) Percentage recovery of preload recruitable stroke work before and after cardiopulmonary bypass (CPB). *p < 0.05 compared with nitroglycerine (TNG) and l-arginine group. #p < 0.05 compared with l-arginine group. (B) Percentage recovery of cardiac index before and after cardiopulmonary bypass *p < 0.05 compared with nitroglycerine and l-arginine groups. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3 Fig 2 (A) Percentage recovery of pulmonary vascular resistance before and after cardiopulmonary bypass (CPB). *p < 0.05 compared with nitroglycerine (TNG), l-arginine group; #p < 0.05 compared with nitroglycerine group. (B) Recovery of systemic pulmonary pressure/systemic arterial pressure ratio (PAP/SAP) before and after cardiopulmonary bypass. *p < 0.05 compared with nitroglycerine, l-arginine group; #p < 0.05 compared with nitroglycerine group. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4 Fig 3 (A) Percentage recovery of alveolar−arterial oxygen tension difference before and after cardiopulmonary bypass (CPB). (N.S. = not significant.) (B) Percentage recovery of lung compliance. *p < 0.05 compared with l-arginine group. The Annals of Thoracic Surgery  , DOI: ( /S (02) )

5 Fig 4 Percentage recovery of bioelectric impedance. (CPB = cardiopulmonary bypass; N.S. = not significant; TNG = nitroglycerine.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

6 Fig 5 (A) Nitric oxide metabolites in the coronary sinus plasma before and after cardiopulmonary bypass. (B) Malondialdehyde (MDA) in heart and lung tissue. (CPB = cardiopulmonary bypass; N.S. = not significant; TNG = nitroglycerine.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

7 Fig 6 (A) Mitochondrial respiratory chain complex activities. (B) Percentage recovery of oxygen extraction ratio before and after cardiopulmonary bypass (CPB). *p < 0.05 control group vs. l–arginine and vs. TNG. (COX = cytochrome c oxidase; N.S. = not significant; TNG = nitroglycerine.) The Annals of Thoracic Surgery  , DOI: ( /S (02) )

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