1. Single-Ventricle Physiology Reduces Cerebral Oxygen Delivery in a Piglet Model 
Marco Ricci, MD, Pierluca Lombardi, MD, Alvaro Galindo, MD, Ernesto Coscarella, MD, Amelia Vasquez, Eliot Rosenkranz, MD 
The Annals of Thoracic Surgery 
Volume 80, Issue 2, Pages (August 2005)
DOI: /j.athoracsur
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2. Fig 1
Regional brain blood flow expressed as percentage change from baseline (gray bars) during the experimental time points (open bars = 30 minutes; hatched bars = 120 minutes). In controls, significant increases in blood flow were seen in the brain as a whole and in several selected brain regions (p < 0.05). In the single-ventricle physiology (SVP) group, regional increases in blood flow were modest (p = not significant), or absent, despite the hypoxemia and reduced arterial oxygen content associated with SVP. *p < 0.05 as compared with baseline by one-way ANOVA. **p < 0.05 as compared with 30 minutes by one-way ANOVA.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3. Fig 2
Regional brain oxygen delivery expressed as percentage change from baseline (gray bars) during the experimental time points (open bars = 30 minutes; hatched bars = 120 minutes). In controls, significant increases in oxygen delivery were seen in the subtentorial regions, cerebellum, and hippocampus (p < 0.05). In the single-ventricle physiology (SVP) group, regional oxygen delivery trended down in nearly all regions after creation of SVP (p = not significant). In the cerebrum, cortex, and white matter the trend in declining oxygen delivery continued at 120 minutes. Intergroup differences (two-way ANOVA) indicating lower oxygen delivery to selected brain regions in the SVP group are shown in the Figure. *p < 0.05 as compared with baseline by one-way ANOVA.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4. Fig 3
Oxygen (O2) consumption and fractional oxygen extraction during the experimental data points. Despite the trend for lower cerebral oxygen delivery and consumption in the single-ventricle physiology (SVP) group, oxygen fractional extraction failed to increase in these animals. None of the intergroup and within-group differences reached statistical significance by one-way and two-way ANOVA. (Gray bars = baseline; open bars = 30 minutes; hatched bars = 120 minutes.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

5. Fig 4
Changes in cerebral oxygen consumption (cerebral metabolic rate [CMRO2]) and cerebral lactate utilization/production (CMRLact) as calculated from sampling the jugular vein versus the sagittal sinus during various experimental data points (n = 9) (2-way ANOVA; p = ns). There were no significant differences between the two techniques. (Solid line triangles = CMRLact jugular vein; dotted line triangles = CMRLact sagittal sinus; solid line boxes = CMRO2 jugular vein; dotted line boxes = CMRO2 sagittal sinus.)
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )
Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions