Presentation is loading. Please wait.

Presentation is loading. Please wait.

Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung  Young Tae Kim, MD, PhD, Sun Jung Park, MS,

Published byBarry Gray Modified over 4 years ago

Similar presentations

Presentation on theme: "Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung  Young Tae Kim, MD, PhD, Sun Jung Park, MS,"— Presentation transcript:

1 Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung  Young Tae Kim, MD, PhD, Sun Jung Park, MS, Seung Hee Lee, BS, Hee Jung Kang, MD, PhD, Seokyung Hahn, PhD, Chang Hyun Kang, MD, Sook Whan Sung, MD, PhD, Joo Hyun Kim, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 130, Issue 5, Pages 1378.e e10 (November 2005) DOI: /j.jtcvs Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Kaplan-Meier curves for overall survival according to the methylation status for the normal tissue RARβP2 (A) and the cancer tissue DAPK (B). The numbers on the graph represent patients remaining at risk. DAPK, Death-associated protein kinase; RARβP2, retinoic acid receptor β-promoter. The Journal of Thoracic and Cardiovascular Surgery  , 1378.e e10DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

3 Figure E1 Representative methylation-specific polymerase chain reaction product of the promoter for p16, RARβP2, DAPK, MGMT, and GSTP1 in tumor and normal tissue from patients with adenocarcinoma of the lung (A) and the result in normal tissue from nonsmoking patients with benign lung disease (B). The presence of product in lane M indicates the presence of methylated genes; the presence of product in lane M indicates the presence of unmethylated genes.DAPK, Death-associated protein kinase; GSTP1, glutathione-S-transferase P1; H2O, water control; IVM, in vitro methylated control; MGMT, O6-methylguanine-DNA-methyltransferase; Nor, normal tissue; Normal, nonsmoking benign patients; Patient, patient with adenocarcinoma; RARβP2, retinoic acid receptor β-promoter; Tum, tumor tissue; U, unmethylation. The Journal of Thoracic and Cardiovascular Surgery  , 1378.e e10DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

4 Figure E2 Cox regression cumulative hazard function for overall survival according to the methylation status for the normal tissue RARβP2 (A) and the cancer tissue DAPK (B). DAPK, Death-associated protein kinase; RARβP2, retinoic acid receptor β-promoter. The Journal of Thoracic and Cardiovascular Surgery  , 1378.e e10DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E3 Cox regression cumulative hazard function for disease-free survival according to methylation status for the normal tissue RARβP2 (A) and DAPK (B). DAPK, Death-associated protein kinase; RARβP2, retinoic acid receptor β-promoter. The Journal of Thoracic and Cardiovascular Surgery  , 1378.e e10DOI: ( /j.jtcvs ) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung  Young Tae Kim, MD, PhD, Sun Jung Park, MS,"

Similar presentations

Blood lactate level during extracorporeal life support as a surrogate marker for survival  Sung Jun Park, MD, Sang-pil Kim, MD, PhD, Joon Bum Kim, MD,

Blood lactate level during extracorporeal life support as a surrogate marker for survival  Sung Jun Park, MD, Sang-pil Kim, MD, PhD, Joon Bum Kim, MD,
Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between.

Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between.
The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer.

The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer.
Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma  Kazuya Takamochi, MD, Shiaki Oh, MD,

Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma  Kazuya Takamochi, MD, Shiaki Oh, MD,
Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.
Is lung cancer resection indicated in patients with idiopathic pulmonary fibrosis?  Atsushi Watanabe, MD, PhD, Tetsuya Higami, MD, PhD, Syunsuke Ohori,

Is lung cancer resection indicated in patients with idiopathic pulmonary fibrosis?  Atsushi Watanabe, MD, PhD, Tetsuya Higami, MD, PhD, Syunsuke Ohori,
A novel detection method of non–small cell lung cancer using multiplexed bead-based serum biomarker profiling  Hyun Joo Lee, MD, PhD, Young Tae Kim, MD,

A novel detection method of non–small cell lung cancer using multiplexed bead-based serum biomarker profiling  Hyun Joo Lee, MD, PhD, Young Tae Kim, MD,
Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.

Who Are Less Likely to Receive Subsequent Chemotherapy Beyond First-Line Therapy for Advanced Non-small Cell Lung Cancer?: Implications for Selection.
Preoperative Serum Fibrinogen Level Predicts Postoperative Pulmonary Complications After Lung Cancer Resection  Suk-Won Song, MD, Hyun-Sung Lee, MD, Moon.

Preoperative Serum Fibrinogen Level Predicts Postoperative Pulmonary Complications After Lung Cancer Resection  Suk-Won Song, MD, Hyun-Sung Lee, MD, Moon.
Long-term outcomes of percutaneous mitral balloon valvuloplasty versus open cardiac surgery  Jae-Kwan Song, MD, Mi-Jeong Kim, MD, Sung-Cheol Yun, PhD,

Long-term outcomes of percutaneous mitral balloon valvuloplasty versus open cardiac surgery  Jae-Kwan Song, MD, Mi-Jeong Kim, MD, Sung-Cheol Yun, PhD,
Volume 148, Issue 1, Pages (January 2018)

Volume 148, Issue 1, Pages (January 2018)
The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR- Mutant Non–Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors 

The BIM Deletion Polymorphism and its Clinical Implication in Patients with EGFR- Mutant Non–Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors 
Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer  Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.

Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer  Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.
Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non–small cell lung cancer 

Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non–small cell lung cancer 
Susan C. Scott, MD, Nathan A. Pennell, MD, PhD 

Susan C. Scott, MD, Nathan A. Pennell, MD, PhD 
Mild-to-moderate functional tricuspid regurgitation in patients undergoing mitral valve surgery  Sun Kyun Ro, MD, Joon Bum Kim, MD, Sung Ho Jung, MD,

Mild-to-moderate functional tricuspid regurgitation in patients undergoing mitral valve surgery  Sun Kyun Ro, MD, Joon Bum Kim, MD, Sung Ho Jung, MD,
Can Aberrant Promoter Hypermethylation of CpG Islands Predict the Clinical Outcome of Non-Small Cell Lung Cancer After Curative Resection?  Young Tae.

Can Aberrant Promoter Hypermethylation of CpG Islands Predict the Clinical Outcome of Non-Small Cell Lung Cancer After Curative Resection?  Young Tae.
The Presence of Mutations in Epidermal Growth Factor Receptor Gene Is Not a Prognostic Factor for Long-Term Outcome after Surgical Resection of Non–Small-Cell.

The Presence of Mutations in Epidermal Growth Factor Receptor Gene Is Not a Prognostic Factor for Long-Term Outcome after Surgical Resection of Non–Small-Cell.
Prognostic signature of early lung adenocarcinoma based on the expression of ribonucleic acid metabolism–related genes  Ruben Pio, PharmD, PhD, Jackeline.

Prognostic signature of early lung adenocarcinoma based on the expression of ribonucleic acid metabolism–related genes  Ruben Pio, PharmD, PhD, Jackeline.
The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non–small cell lung cancer  Kyong-Ah Yoon,

The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non–small cell lung cancer  Kyong-Ah Yoon,

Similar presentations

Ads by Google