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Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between.

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Presentation on theme: "Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between."— Presentation transcript:

1 Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between Primary Non-small Cell Lung Cancer and Metastatic Lymph Nodes and the Significance in Mid- Term Survival  Chang Hyun Kang, MD, Bo Gun Jang, MD, Dong-Wan Kim, MD, Doo Hyun Chung, MD, Young Tae Kim, MD, Sanghoon Jheon, MD, Sook-Whan Sung, MD, Joo Hyun Kim, MD  Journal of Thoracic Oncology  Volume 4, Issue 11, Pages (November 2009) DOI: /JTO.0b013e3181b9f236 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Immunohistochemical staining of (A) excision repair crosscomplementation group 1 (ERCC1), (B) x-ray repair crosscomplementation group 1 (XRCC1), and (C) βIII-tubulin. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181b9f236) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 A, Changes in excision repair crosscomplementation group 1 (ERCC1) expression in primary tumors and metastatic lymph nodes. B, Fifty-five percent of patients showed upregulation of metastatic lymph nodes, but downregulation was found in only 8% of patients. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181b9f236) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 A, Changes in x-ray repair crosscomplementation group 1 (XRCC1) expression in primary tumors and metastatic lymph nodes. B, Fifty-six percent of patients showed upregulation of XRCC1 expression, but only 6% of patients showed downregulation. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181b9f236) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 A, Changes in βIII-tubulin expression in primary tumor and metastatic lymph nodes. B, βIII-Tubulin expression in metastatic lymph nodes was downregulated in 45% of patients compared with 12% upregulation. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181b9f236) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 Overall survival according to the level of excision repair crosscomplementation group 1 (ERCC1) expression. A, Patients with upregulation of ERCC1 expression in N1 lymph nodes compared with the primary tumor site demonstrate significantly poor prognosis in N1 non-small cell lung cancer (p = 0.024). B, It shows survival curves according to ERCC1 up- or downregulation in N2 lymph nodes. However, the change in ERCC1 expression in N2 lymph node did not affect overall survival. Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181b9f236) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

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