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Can Aberrant Promoter Hypermethylation of CpG Islands Predict the Clinical Outcome of Non-Small Cell Lung Cancer After Curative Resection?  Young Tae.

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Presentation on theme: "Can Aberrant Promoter Hypermethylation of CpG Islands Predict the Clinical Outcome of Non-Small Cell Lung Cancer After Curative Resection?  Young Tae."— Presentation transcript:

1 Can Aberrant Promoter Hypermethylation of CpG Islands Predict the Clinical Outcome of Non-Small Cell Lung Cancer After Curative Resection?  Young Tae Kim, MD, PhD, Seung Hee Lee, BS, Sook Whan Sung, MD, PhD, Joo Hyun Kim, MD, PhD  The Annals of Thoracic Surgery  Volume 79, Issue 4, Pages (April 2005) DOI: /j.athoracsur Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Representative MSP of the promoter of p16INK4a, RARβP2, DAPK, and MGMT in NSCLC. The presence of product in Lane U indicates the presence of unmethylated genes; the presence of product in Lane M indicates the presence of methylated genes. (bp = base pair; DAPK = death-associated protein kinase; M = methylation; MGMT = O6-methylguanine-DNA-methyltransferase; MSP = methylation-specific polymerase chain reaction; N = negative control; Nor = normal; NSCLC = nonsmall cell lung cancer; P = positive control; RARβP2 = retinoic acid receptor β-promoter; Tum = tumor; U = unmethylation.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Immunohistochemical staining for RARβ (original magnification x200). There was no correlation between the methylation status and immunohistochemical staining result: (A) strong positive; (B) negative. (RARβP2 = retinoic acid receptor β-promoter.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Cox hazard model analysis for freedom from recurrence in the remaining lung according to the (A) RARβP2 and (B) DAPK methylation status = unmethylated; — = methylated. (DAPK = death-associated protein kinase; RARβP2 = retinoic acid receptor β-promoter.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

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