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Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,

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Presentation on theme: "Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,"— Presentation transcript:

1 Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc.
Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A, Representative TH immunohistochemistry and Nissl staining of midbrain sections from SNpc of PGC-1αflox/flox mice injected with AAV-GFP or AAV-Cre-GFP 6 months after the injection of virus. Scale bar, 100 µm. B, Stereological assessment of TH- and Nissl-positive neurons in the SNpc of PGC-1αflox/flox mice injected with AAV-GFP or AAV-Cre-GFP (n = 3/group). C, HPLC assessment of the striatal content of dopamine. D, HPLC assessment of the striatal content of dopamine metabolites DOPAC and HVA. E, Amphetamine-induced ipsilateral rotations (n = 3/group). Data are expressed as the mean ± SEM. *p < 0.05, **p < Inj, Injected; n.s, not significant. Haisong Jiang et al. eneuro 2016;3:ENEURO ©2016 by Society for Neuroscience

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