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Fig. 5. Testis defects in STK35 KO mice.

Published byUtami Widyawati Atmadja Modified over 4 years ago

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Presentation on theme: "Fig. 5. Testis defects in STK35 KO mice."— Presentation transcript:

1 Fig. 5. Testis defects in STK35 KO mice.
Testis defects in STK35 KO mice. (A) Representative image of STK35 WT (+/+) and KO (−/−) testes. Scale bars: 5 mm. (B) Graph showing testis/body weight ratio of KO mice was significantly lower than for WT or Het mice. (C) Western blot confirming STK35 proteins are absent in KO mouse testis (arrows). (D) Histological comparison of STK35 WT and KO tissues revealed severe disruption in spermatogenesis in KO testes. Sertoli cell only (SCO) tubule and Sertoli cell cluster indicated by arrowhead. (E) Western blot analysis of phospho-Histone H2A.X on WT and KO mice testes. (F) Immunohistochemical analysis of STK35 WT and KO testis sections with MVH, AMH, SOX9 and CX43 antibodies. Cellular localization of MVH, SOX9 and CX43 proteins are shown in adult mouse testis, and AMH in 21 dpp mouse testis. A representative negative control image for each antibody is shown on WT (inset). Sertoli cell only tubules and Sertoli cell clusters indicated by SCO and arrowheads respectively. Scale bars: 50 µm for D,F and are representative of corresponding KO image. Yoichi Miyamoto et al. Biology Open 2018;7:bio032631 © Published by The Company of Biologists Ltd

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