1. Trans-acting factors show enrichment of putative targets among differentially translated genes under DR.
Trans-acting factors show enrichment of putative targets among differentially translated genes under DR. (A) RBP motifs significantly enriched in 3′ UTRs among differentially translated genes. Black line represents significance threshold of P < The CISBP-RNA database motif ID associated with each RBP is given in parenthesis. (B) Regulation of RBP genes with enriched motifs under DR. Fold change in the translated fraction is given. (C) RNAi of RBP genes sup-26 (P = 1.39 × 10−04), pab-1 (P = 2.60 × 10−06), and unc-75 (P = 2.6 × 10−06) but not mex-5 (P = 0.19) nor asd-2 (P = 0.585) extend median life span under well-fed conditions compared with controls (n > 80, log-rank test). Representative life spans are shown; full dataset found in Table S8.
Jarod A Rollins et al. LSA 2019;2:e
© 2019 Rollins et al.