1. Fig. 7 Bacterial dependency networks in IgA deficiency and HDs.
Bacterial dependency networks in IgA deficiency and HDs. (A) For each individual and each MGS-MGS dependency, there are four possible situations. If the satellite MGS is present without corresponding host MGS, then the link is considered lost. If the satellite and host are both present, then the link is considered conserved. If the host is present in the absence of the satellite, or if both host and satellite are absent, then no information is given about the link. (B) Distribution of the percentage of confirmed MGS-MGS dependency links. (C) MGS-MGS dependency network compared between HDs (left) and SIgAd patients (right). Each of the two network maps shows the expected 45 highly significant and directional dependencies among 60 MGSs, as defined by Nielsen et al. (32). Blue circles represent host MGSs. Purple triangles represent satellite MGSs. A purple triangle within a blue circle indicates both satellite and host status. Black arrows indicate the confirmed dependencies among MGSs (directional arrow from the satellite MGS to the host MGS). Red crosses indicate lost dependencies in HDs and IgA deficiency.
Jehane Fadlallah et al., Sci Transl Med 2018;10:eaan1217
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works