1. csEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy.
csEN components reveal precisely timed cellular programs that characterize the dynamic changes of the peripheral immune system over the course of pregnancy. (A) The correlation network segregated into 20 communities containing correlated immune features that changed in synchronicity during pregnancy. (B) The 20 communities were annotated on the basis of immune feature attributes (cell subset, stimulation, or signaling property) most commonly represented within each community. (C) Communities containing csEN components most predictive of gestational age are highlighted (red dots) and shown in table S3. Community numbers are indicated in red. (D to I) The five communities containing the most informative EN components of the csEN model (see fig. S2 and table S4). Communities are represented on the left. Graphs on the right depict csEN components (black lines represent each patient; red lines and red shadow represent median and 95% confidence interval, n =18).
Nima Aghaeepour et al. Sci. Immunol. 2017;2:eaan2946
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