Presentation is loading. Please wait.

Presentation is loading. Please wait.

Genome-wide interaction study of dust mite allergen on lung function in children with asthma  Erick Forno, MD, MPH, Joanne Sordillo, MD, MPH, John Brehm,

Published byEija Hänninen Modified over 5 years ago

Similar presentations

Presentation on theme: "Genome-wide interaction study of dust mite allergen on lung function in children with asthma  Erick Forno, MD, MPH, Joanne Sordillo, MD, MPH, John Brehm,"— Presentation transcript:

1 Genome-wide interaction study of dust mite allergen on lung function in children with asthma 
Erick Forno, MD, MPH, Joanne Sordillo, MD, MPH, John Brehm, MD, MPH, Wei Chen, PhD, Takis Benos, PhD, Qi Yan, PhD, Lydiana Avila, MD, Manuel Soto-Quirós, MD, Michelle M. Cloutier, MD, Angel Colón-Semidey, MD, Maria Alvarez, MD, Edna Acosta-Pérez, PhD, Scott T. Weiss, MD, MS, Augusto A. Litonjua, MD, MPH, Glorisa Canino, PhD, Juan C. Celedón, MD, DrPH, FAAAAI  Journal of Allergy and Clinical Immunology  Volume 140, Issue 4, Pages e7 (October 2017) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Journal of Allergy and Clinical Immunology 2017 140, 996-1003
Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 1 Manhattan plot of genome-wide interaction study interaction P values in PRGOAL for FEV1. Plot depicts the –log10(interaction P value) for FEV1 on the y-axis versus SNPs in each chromosome on the x-axis. Red line: genome-wide significance level (P < 5 × 10−8). Blue line: genome-wide suggestive level (P < 1 × 10−7). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 2 Regional association plot for SNP rs Regional association plot generated using the LocusZoom tool from the Abecasis lab at the University of Michigan ( with data imputed from the 1000 Genomes populations (phase I v3). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 3 FEV1 stratified by rs genotype and dust mite allergen level. FEV1 in PRGOAL stratified by dust mite allergen level (low in blue vs high in red) and rs genotype (AA = no minor alleles vs AC = 1 minor allele; there were no subjects homozygous for the minor allele [CC]). Model adjusted for age, sex, and height. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 4 CEBPβ in the IL-17 signaling pathway. IL-17 pathway (simplified). CEBPβ is one of the mediators of IL-17A and IL-17F signaling pathways, as well as nuclear factor kappa B signaling.37,38 CEBPβ is also involved in IL-4, IL-6, and other signaling pathways (not shown). ERK, Extracellular signal-regulated kinase; GSK3β, glycogen synthase kinase 3 beta; NFκB, nuclear factor kappa B; TAK1, transforming growth factor beta 1-activated kinase 1; TRAF-6, Tumor necrosis factor receptor-associated factor 6. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E1 Regional linkage disequilibrium (LD) plots of the 3 top SNPs for FEV1. LD plots generated at the SNP Annotation and Proxy Search (SNAP) Web site ( using data from the 1000 Genomes Pilot 1. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Genome-wide interaction study of dust mite allergen on lung function in children with asthma  Erick Forno, MD, MPH, Joanne Sordillo, MD, MPH, John Brehm,"

Similar presentations

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans  Rachel A. Myers, PhD, Blanca E. Himes,

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans  Rachel A. Myers, PhD, Blanca E. Himes,
Gun Violence, African Ancestry, and Asthma

Gun Violence, African Ancestry, and Asthma
Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O
Päivi M. Salo, PhD, Samuel J

Päivi M. Salo, PhD, Samuel J
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,
Sunita Sharma, MD, MPH, Augusto Litonjua, MD, MPH 

Sunita Sharma, MD, MPH, Augusto Litonjua, MD, MPH 
Vitamin D Insufficiency and Asthma in a US Nationwide Study

Vitamin D Insufficiency and Asthma in a US Nationwide Study
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Sunita Sharma, MD, MPH, Xiaobo Zhou, PhD, Derek M

Sunita Sharma, MD, MPH, Xiaobo Zhou, PhD, Derek M
Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children  Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,

Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children  Supinda Bunyavanich, MD, MPH, Sheryl L. Rifas-Shiman,
Genome-wide association study of lung function phenotypes in a founder population  Tsung-Chieh Yao, MD, PhD, Gaixin Du, MS, Lide Han, PhD, Ying Sun, MS,

Genome-wide association study of lung function phenotypes in a founder population  Tsung-Chieh Yao, MD, PhD, Gaixin Du, MS, Lide Han, PhD, Ying Sun, MS,
Decreased response to inhaled steroids in overweight and obese asthmatic children  Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss,

Decreased response to inhaled steroids in overweight and obese asthmatic children  Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss,
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study  John M. Brehm, MD, MPH, Brooke Schuemann, BS,
A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom  Yize I. Wan, BMedSci, David P. Strachan,

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom  Yize I. Wan, BMedSci, David P. Strachan,
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans  Rachel A. Myers, PhD, Blanca E. Himes,

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans  Rachel A. Myers, PhD, Blanca E. Himes,
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels  Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels  Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype  Manuel A.R. Ferreira, PhD, Melanie C.

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype  Manuel A.R. Ferreira, PhD, Melanie C.
Prematurity, atopy, and childhood asthma in Puerto Ricans

Prematurity, atopy, and childhood asthma in Puerto Ricans

Similar presentations

Ads by Google