1. Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC.
Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. (A) Venn diagram shows the number of pathways identified by Ingenuity pathway analysis for three groups of genes: regulated in the kidney development model [MM (96 versus 0 h)], regulated in renal carcinoma patients (ccRCC), and genes simultaneously regulated in both groups. The full pathway list is shown in Table S3. (B) Ingenuity pathway analysis of the genes with differential expression in both the ccRCC and the 96-h-induced MMs showing significantly modulated pathways (P<0.05). The 15 top pathways with significant changes are shown. The P-value for each pathway is indicated by the bar and is expressed as −1 times the log of the P-value. The line connecting the orange squares represents the ratio of the number of genes in a given pathway that meet the cutoff criteria to the total number of genes which belong to the pathway.
Qi Xu et al. Dis. Model. Mech. 2017;10:
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