1. OA and related amines modulate motility and length of schistosomula.
OA and related amines modulate motility and length of schistosomula. Using D7 schistosomula, concentration-response assays (1-500 μM) were performed over 20 min with four tyrosine derivatives previously determined to cause significant changes in motility at 500 μM (Fig. 5). The mean relative motility (A-D) and length (E-H) were measured by normalization to each well, at baseline. Means and s.e.m. from a minimum of two experiments with a minimum of two replicates per experiment are shown (n=36). The data presented at the 500 µM concentration are distinct from the data presented in Fig. 5. Significance of the mean values, compared with controls, was determined using the unpaired two-tailed Student's t-test: P-values <0.05*, <0.005**, <0.0005*** and < **** were considered significant.
Nelly El-Sakkary et al. Dis. Model. Mech. 2018;11:dmm033563
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