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Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced in differentiating 22q11.2DS hiPSCs. Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced.

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Presentation on theme: "Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced in differentiating 22q11.2DS hiPSCs. Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced."— Presentation transcript:

1 Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced in differentiating 22q11.2DS hiPSCs.
Acetylation of histone 3 in MEF2C and GATA4 loci is enhanced in differentiating 22q11.2DS hiPSCs. (A,B) Localization of primer pairs (arrows) used for ChIP experiments with human cells on MEF2C and GATA4 genes. ‘AHF Enhancer’ indicates a region of high similarity with the murine AHF enhancer. For reference, we report ENCODE ChIP-seq data for H3K27Ac for two cell types, undifferentiated human embryonic stem cells (H1-hESC) and human skeletal muscle myoblasts (HSMM). The GATA4 promoter region is not acetylated in these two cell types. (C) ChIP assays with an anti-AcH3 antibody in differentiating control and 22q11.2DS hiPSCs, followed by quantitative real-time PCR. Luna Simona Pane et al. Dis. Model. Mech. 2018;11:dmm029967 © Published by The Company of Biologists Ltd

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