1. Representative photomicrographs of morphologic changes in mouse kidneys after injection with 225Ac-labeled antibody.
Representative photomicrographs of morphologic changes in mouse kidneys after injection with 225Ac-labeled antibody. (A through C) At 10 wk, isolated tubular cell swelling, lysis, and karyorrhexis (arrows); normal juxtaglomerular (JG) cells (arrowheads); and negative TGF-β1 staining. (D through F) At 20 wk, varying tubulolysis (arrows), increased JG cells (arrowheads), and focal TGF-β1–positive tubular and interstitial cells (*). (G through I) At 25 wk, widespread tubulolysis with empty tubular basement membrane (TBM) profiles (arrows), increased JG cells (arrowheads), and increased TGF-β1—positive cells (*). Magnification, ×400 in A and B; ×160 in C through F, H, and I.
Jaspreet Singh Jaggi et al. JASN 2005;16:
©2005 by American Society of Nephrology