Presentation is loading. Please wait.

Presentation is loading. Please wait.

Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen– allergic patients  Verena Niederberger, MD, Katharina Marth, MD,

Published byBertram Murphy Modified over 5 years ago

Similar presentations

Presentation on theme: "Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen– allergic patients  Verena Niederberger, MD, Katharina Marth, MD,"— Presentation transcript:

1 Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen– allergic patients  Verena Niederberger, MD, Katharina Marth, MD, Julia Eckl-Dorna, MD, PhD, Margarete Focke-Tejkl, PhD, Milena Weber, MSc, Wolfgang Hemmer, PhD, Uwe Berger, MBA, Angela Neubauer, PhD, Frank Stolz, PhD, Rainer Henning, PhD, Rudolf Valenta, MD  Journal of Allergy and Clinical Immunology  Volume 136, Issue 4, Pages e8 (October 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Comparison of immediate SPT reactions to grass pollen extract, BM32, and individual BM32 components. Mean wheal areas (mm2, y-axis) induced with codein phosphate, grass pollen extract, and 3 concentrations (11, 33, 100 μg/mL) of BM32, BM321, BM322, BM325, and BM326 (x-axis) in the 60 study participants are displayed. Horizontal bars denote medians. The dotted line indicates the cutoff. Calculation: (1.5 mm2 × π) = 7.07 mm2. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 Schematic representation of BM32 components BM321, BM322, BM325, and BM326 showing the sequences of the allergen-derived peptides and their position in the PreS fusion proteins. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 Exposure of study participants to grass pollen during the study. The x-axis displays the time of grass pollen exposure in Vienna from April 1 to August 31. The y-axis shows pollen counts (gray line, grains per m3) as well as the number of subjects enrolled at the respective time points (red columns). Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 Comparison of IgE reactivities to recombinant allergens and BM32 components in the study population. Shown are IgE levels (y-axis, OD values) specific for each of the allergens and the corresponding BM32 components (x-axis). Mean IgE levels are indicated by horizontal bars. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E4 Correlation of timothy grass pollen allergen-specific IgE with recombinant allergen-specific IgE in the study population. Shown are IgE levels to timothy grass pollen extract (x-axis) and the sums of IgE levels to Phl p 1, Phl p 2, Phl p 5, and Phl p 6 (y-axis) in kUA/L. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen– allergic patients  Verena Niederberger, MD, Katharina Marth, MD,"

Similar presentations

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,
Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.
Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study  Anna.
Volume 11, Pages (September 2016)

Volume 11, Pages (September 2016)
Comparison of the immunogenicity of BM32, a recombinant hypoallergenic B cell epitope–based grass pollen allergy vaccine with allergen extract–based vaccines 

Comparison of the immunogenicity of BM32, a recombinant hypoallergenic B cell epitope–based grass pollen allergy vaccine with allergen extract–based vaccines 
Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.
Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R

Kuan-Wei Chen, PhD, Katharina Blatt, MSc, Wayne R
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity  Fabio Dall'Antonia, PhD, Anna Gieras,

Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity  Fabio Dall'Antonia, PhD, Anna Gieras,
Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments  Raffaela Campana, PhD, Katharina.

Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments  Raffaela Campana, PhD, Katharina.
Determination of allergen specificity by heavy chains in grass pollen allergen–specific IgE antibodies  Elisabeth Gadermaier, PhD, Sabine Flicker, PhD,

Determination of allergen specificity by heavy chains in grass pollen allergen–specific IgE antibodies  Elisabeth Gadermaier, PhD, Sabine Flicker, PhD,
Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut  Claudia.
Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy  Margarete Focke-Tejkl, PhD, Milena.

Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy  Margarete Focke-Tejkl, PhD, Milena.
Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy  Raphaela.

Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy  Raphaela.
Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule  Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,

Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule  Carine Metz-Favre, MD, Birgit Linhart, PhD, Margarete Focke-Tejkl, PhD,
Delineating the specificity of an IgE-encoding transcriptome

Delineating the specificity of an IgE-encoding transcriptome
Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds  Sofía Sirvent, PhD, Belén Cantó, BSc, Javier Cuesta-Herranz, MD, PhD,

Act d 12 and Act d 13: Two novel, masked, relevant allergens in kiwifruit seeds  Sofía Sirvent, PhD, Belén Cantó, BSc, Javier Cuesta-Herranz, MD, PhD,
Safety and efficacy of immunotherapy with the recombinant B-cell epitope–based grass pollen vaccine BM32  Verena Niederberger, MD, Angela Neubauer, PhD,

Safety and efficacy of immunotherapy with the recombinant B-cell epitope–based grass pollen vaccine BM32  Verena Niederberger, MD, Angela Neubauer, PhD,
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  Julie Wang, MD,

Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy  Julie Wang, MD,

Similar presentations

Ads by Google