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DCT-CA-SPAK decreases Rhcg expression and H-ATPase apical polarization in the inner stripe of the outer medulla. DCT-CA-SPAK decreases Rhcg expression.

Published byἸοκάστη Κουταλιανός Modified over 5 years ago

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Presentation on theme: "DCT-CA-SPAK decreases Rhcg expression and H-ATPase apical polarization in the inner stripe of the outer medulla. DCT-CA-SPAK decreases Rhcg expression."— Presentation transcript:

1 DCT-CA-SPAK decreases Rhcg expression and H-ATPase apical polarization in the inner stripe of the outer medulla. DCT-CA-SPAK decreases Rhcg expression and H-ATPase apical polarization in the inner stripe of the outer medulla. Subfigure (A) shows high-power micrographs of Rhcg immunolabel in the CCD (top row), and OMCDis (bottom row) of WT (left column) and DCT-CA-SPAK (right column) kidney. Subfigure (B) shows Rhcg expression by immunoblot analysis. Subfigure (C) shows high-power micrographs of a4-H+-ATPase immunolabel in the CCD (top row), and OMCDis (bottom row) of WT (left column) and DCT-CA-SPAK (right column) kidney. Subfigure (D) shows quantification of the percent of total cellular a4-H+-ATPase in the apical 1.5 µm of intercalated cells in the OMCDis of WT and DCT-CA-SPAK mice. n=4 in each group in all subfigures. *CCD segments. DCT-CA-SPAK, mice with early DCT-specific over-expression of constitutively active SPAK; IHC, immunohistochemistry; WT, wild-type mice. Autumn N. Harris et al. JASN 2018;29: ©2018 by American Society of Nephrology

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