1. How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection 
Delphine Javelaud, Aurélien De Reyniès, Alain Mauviel 
Journal of Investigative Dermatology Symposium Proceedings 
Volume 19, Issue 2, Pages S87-S88 (December 2018)
DOI: /j.jisp
Copyright © 2018 The Authors Terms and Conditions

2. Figure 1
Crosstalk between TGF-β and HH signaling. TGF-β ligand binding to its receptors activates the SMAD cascade, resulting in transcriptional activation of GLI2. GLI2 protein may either regulate target gene expression downstream of TGF-β signaling or feed into to HH-driven signaling, which occurs via SMO activation within the primary cilium in response to HH binding to its receptor PTCH1. HH, Hedgehog.
Journal of Investigative Dermatology Symposium Proceedings  , S87-S88DOI: ( /j.jisp )
Copyright © 2018 The Authors Terms and Conditions