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Volume 114, Issue 2, Pages (February 1998)

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Presentation on theme: "Volume 114, Issue 2, Pages (February 1998)"— Presentation transcript:

1 Volume 114, Issue 2, Pages 336-343 (February 1998)
Increased adrenomedullin levels in cirrhosis: Relationship with hemodynamic abnormalities and vasoconstrictor systems  Mónica Guevara, Pere Ginès, Wladimiro Jiménez, Pau Sort, Glòria Fernández-Esparrach, Angels Escorsell, Ramón Bataller, Jaume Bosch, Vicente Arroyo, Francisca Rivera, Juan Rodés  Gastroenterology  Volume 114, Issue 2, Pages (February 1998) DOI: /S (98)70486-X Copyright © 1998 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Circulating levels of AM in plasma samples obtained from a peripheral vein of healthy subjects, cirrhotic patients without ascites, and cirrhotic patients with ascites. P < P < 0.05 (ANOVA) for patients with ascites compared with patients without ascites and healthy subjects. Gastroenterology  , DOI: ( /S (98)70486-X) Copyright © 1998 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Relationship between circulating AM levels and (A) mean arterial pressure (MAP) and (B) heart rate (HR) in cirrhotic patients included in protocol 1. Gastroenterology  , DOI: ( /S (98)70486-X) Copyright © 1998 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Relationship between circulating AM levels and endothelin levels in cirrhotic patients included in protocol 1. Gastroenterology  , DOI: ( /S (98)70486-X) Copyright © 1998 American Gastroenterological Association Terms and Conditions

5 Fig. 4 AM levels in plasma samples obtained from hepatic vein, renal vein, femoral artery, and pulmonary artery from cirrhotic patients with ascites included in protocol 2. No significant differences were observed. Gastroenterology  , DOI: ( /S (98)70486-X) Copyright © 1998 American Gastroenterological Association Terms and Conditions

6 Fig. 5 (A) PRA and (B) circulating AM levels in baseline conditions and after expansion of plasma volume with 1 g/kg of human serum albumin in 8 cirrhotic patients with ascites included in protocol 3. Gastroenterology  , DOI: ( /S (98)70486-X) Copyright © 1998 American Gastroenterological Association Terms and Conditions


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