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Volume 146, Issue 5, Pages e6 (May 2014)

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1 Volume 146, Issue 5, Pages 1231-1239.e6 (May 2014)
A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis  José Altamirano, Rosa Miquel, Aezam Katoonizadeh, Juan G. Abraldes, Andrés Duarte–Rojo, Alexandre Louvet, Salvador Augustin, Rajeshwar P. Mookerjee, Javier Michelena, Thomas C. Smyrk, David Buob, Emmanuelle Leteurtre, Diego Rincón, Pablo Ruiz, Juan Carlos García–Pagán, Carmen Guerrero–Marquez, Patricia D. Jones, A. Sidney Barritt, Vicente Arroyo, Miquel Bruguera, Rafael Bañares, Pere Ginès, Juan Caballería, Tania Roskams, Frederik Nevens, Rajiv Jalan, Philippe Mathurin, Vijay H. Shah, Ramón Bataller  Gastroenterology  Volume 146, Issue 5, Pages e6 (May 2014) DOI: /j.gastro Copyright © 2014 AGA Institute Terms and Conditions

2 Figure 1 Histologic features independently associated with 90-day survival included in the Histologic AHHS. (A–C) Degree of fibrosis (Masson trichrome staining): portal fibrosis, expansive areas of liver fibrosis, and cirrhosis, respectively. H&E stain. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

3 Figure 2 Histologic features independently associated with 90-day survival included in the Histologic AHHS. (A) Hepatocellular and canalicular bilirubinostasis (arrow). (B) Ductular bilirubinostasis (arrow). (C) Megamitochondria (arrows). (D and E) Mild and severe PMN infiltration, respectively (arrow). H&E stain. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

4 Figure 3 Three-month survival probability of patients with AH according to the Histologic AHHS in the (A) study and (B) validation cohorts. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

5 Figure 4 (A) Three-month survival probability of patients with ABIC class B according to the AHHS. (B) Three-month survival probability of patients with a MELD score <21 according to the AHHS. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

6 Supplementary Figure 1 Three-month probability of survival in patients with AH treated with corticosteroids according to the AHHS). Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

7 Supplementary Figure 2 Predicted vs observed mortality in the validation set according to the AHHS. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

8 Supplementary Figure 3 Type of bilirubinostasis and infections during hospitalizations in patients with AH. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

9 Supplementary Figure 4 Type of bilirubinostasis and baseline serum bilirubin levels. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

10 Supplementary Figure 5 Side-by-side comparison of AHHS, ABIC score, and MELD score for predicting 90-day mortality in the complete cohort. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

11 Supplementary Figure 6 Differences in the MELD score between patients with an AHHS ≥5 points and an AHHS <5 points. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

12 Supplementary Figure 7 Measurement of HVPG in patients with an AHHS ≥5 points and an AHHS <5 points in the complete cohort. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions

13 Supplementary Figure 8 AUROC for agreement between predicted and observed probabilities of mortality. AUROC, area under the receiver operating characteristic curve. Gastroenterology  , e6DOI: ( /j.gastro ) Copyright © 2014 AGA Institute Terms and Conditions


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