1. GPR120 deficiency alters the expression of genes involved in glucose and lipid metabolism in BAT
GPR120 deficiency alters the expression of genes involved in glucose and lipid metabolism in BAT AProbe sets for WT and GPR120 KO BAT from microarray analysis are colored according to average expression levels across all samples, with green denoting a higher expression level and red denoting a lower expression level. The probe sets shown in the heat map passed the threshold of absolute value of the logFC > 0.5 and P‐adjusted < 0.05.B–EExpression of genes involved in inflammation, adipocyte biology, glucose metabolism, and lipid metabolism in BAT from GPR120 KO mice (n = 5) and WT littermates (n = 6) was determined through qRT–PCR (N.D. = non‐detectable). Data represent means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared to the WT control group, according to the two‐tailed unpaired Student's t‐test. The exact P‐value for each significant difference can be found in Appendix Table S5.
Maaike Schilperoort et al. EMBO Mol Med. 2018;emmm
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