1. Hyp mice show hypertension and increased NCC expression and phosphorylation A–ESerum intact Fgf23 concentration (A, n = 8–9, Student's t‐test, *P =  versus vehicle); heart‐to‐body weight ratio, serum Na+ and urinary Na+ excretion corrected by urinary creatinine (Crea) (B); mean arterial blood pressure (C, n = 8–9, Student's t‐test, *P < 0.05 versus vehicle); Western blotting quantification of renal NCC membrane expression and NCC phosphorylation at Ser71, Ser91, and Thr55 (pNCC S71, pNCC S91, pNCC T55) (n = 8–9) (D); and urinary aldosterone corrected by urinary creatinine and serum aldosterone concentrations in 3‐month‐old male wild‐type (WT) and Hyp mice (n = 8–9, Student's t‐test, *P < 0.05 versus vehicle) (E).
Hyp mice show hypertension and increased NCC expression and phosphorylation A–ESerum intact Fgf23 concentration (A, n = 8–9, Student's t‐test, *P =  versus vehicle); heart‐to‐body weight ratio, serum Na+ and urinary Na+ excretion corrected by urinary creatinine (Crea) (B); mean arterial blood pressure (C, n = 8–9, Student's t‐test, *P < 0.05 versus vehicle); Western blotting quantification of renal NCC membrane expression and NCC phosphorylation at Ser71, Ser91, and Thr55 (pNCC S71, pNCC S91, pNCC T55) (n = 8–9) (D); and urinary aldosterone corrected by urinary creatinine and serum aldosterone concentrations in 3‐month‐old male wild‐type (WT) and Hyp mice (n = 8–9, Student's t‐test, *P < 0.05 versus vehicle) (E). Data represent mean ± s.e.m. Source data are available for this figure.
Olena Andrukhova et al. EMBO Mol Med. 2014;emmm
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