1. Nat. Rev. Cardiol. doi:10.1038/nrcardio.2015.137
Figure 2 Effects of conventional versus novel inotropes on cardiac contractility in vivo
Figure 2 | Effects of conventional versus novel inotropes on cardiac contractility in vivo. The effects of dobutamine and omecamtiv mercabil on time-dependent elastance were compared in dogs with heart failure induced by chronic rapid cardiac pacing together with localized myocardial infarction. TE[max] and TE[min] at baseline are shown, along with the changes induced on treatment. Whereas the conventional inotrope dobutamine increased stroke volume from baseline via increases in the rate of left ventricular pressure increase, omecamtiv mecarbil prolonged ejection time in the absence of alterations in this rate. Abbreviations: TE[max], time to maximum elastance; TE[min], time to minimum elastance. Permission obtained from the American Association for the Advancement of Science © Malik, F. I. et al. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science 331, 1439–1443 (2011).
Permission obtained from the American Association for the Advancement of Science © Malik, F. I. et al. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science 331, 1439–1443 (2011)
von Lueder, T. G. & Krum, H. (2015) New medical therapies for heart failure
Nat. Rev. Cardiol. doi: /nrcardio