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Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?  Gun-II Im, M.D., Yong-Woon.

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Presentation on theme: "Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?  Gun-II Im, M.D., Yong-Woon."— Presentation transcript:

1 Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?  Gun-II Im, M.D., Yong-Woon Shin, M.D., Kee-Byung Lee, M.D.  Osteoarthritis and Cartilage  Volume 13, Issue 10, Pages (October 2005) DOI: /j.joca Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

2 Fig. 1 Immunofluorescent staining for STRO-1 in BMMSCs (A); ATMSCs (B); peripheral blood monocyte (C), and CD34 in BMMSCs (D); ATMSCs (E); peripheral blood monocyte (F). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

3 Fig. 2 AP staining of BMMSCs after 2 weeks of culture in OM (A); control medium (B), and ATMSCs after 2 weeks of culture in OM (C); control medium (D). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

4 Fig. 3 Von Kossa staining of BMMSCs after 3 weeks of culture in OM medium (A); control medium (B), and ATMSCs after 3 weeks of culture in OM (C); control medium (D). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

5 Fig. 4 The appearance of BMMSCs (A) and ATMSCs (B) in the fibrin culture (5 days after seeding). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

6 Fig. 5 Chondrogenesis in the pellet culture. Hematoxylin eosin staining of BMMSCs cultured in CM (A); in control medium (B), ATMSCs cultured in CM (C); in control medium (D) after 4 weeks of culture. Safranin-O staining of BMMSCs in CM (E); in control medium (F), ATMSCs cultured in CM (G); in control medium (H). Immunohistochemical staining for type II collagen of BMMSCs in CM (J); in control medium (K), ATMSCs cultured in CM (L); in control medium (M). Normal human articular cartilage and subchondral bone were used as the control for Safranin-O staining (I) and type II collagen staining (N). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

7 Fig. 6 Chondrogenesis in the fibrin gel culture. Hematoxylin eosin staining of BMMSCs cultured in CM (A); in control medium (B), ATMSCs cultured in CM (C); in control medium (D) after 4 weeks of culture. Safranin-O staining of BMMSCs in CM (E); in control medium (F), ATMSCs cultured in CM (G); in control medium (H). Immunohistochemical staining for type II collagen of BMMSCs in CM (I); in control medium (J), ATMSCs cultured in CM (K); in control medium (L). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

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