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Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.

Published byΛαύρα Στεφανόπουλος Modified over 5 years ago

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Presentation on theme: "Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα."— Presentation transcript:

1 Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.
CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. (A) GBM expressing high amounts of CSPG4 (BT168) shows a high number of Iba1+ cells identified as microglia. (B) The only GBM negative for CSPG4 expression (BT274) in our cohort shows a total lack of Iba1+ cells. (C) Correlation of the percentage of CSPG4-positive tumor cells and Iba1-positive cells in the tumor mass (linear regression, P = 0.04). The cutoff for Iba1 expression was set at 10%. (D) Representative GBM specimen evaluated by immunofluorescence shows the presence of Iba1+ cells (green) coexpressing TNFα (merge). Two different areas are shown at two magnifications (scale bars, 25 μm). Nuclei are visualized by DAPI staining. Serena Pellegatta et al., Sci Transl Med 2018;10:eaao2731 Published by AAAS

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