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Fig. 3. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with ARC-520. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with.

Published byمحمدعلي کمالی Modified over 5 years ago

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Presentation on theme: "Fig. 3. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with ARC-520. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with."— Presentation transcript:

1 Fig. 3. Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with ARC-520.
Serum HBsAg and liver HBV mRNA reduction in chimpanzees dosed with ARC-520. After prestudy evaluation, nine chimpanzees began NUC dosing for a lead-in period of 8 to 24 weeks. Q4W dosing with ARC-520 began on day 1. Liver mRNA from biopsies of HBeAg-positive chimpanzees (A2A004, A3A006, and A4A014) and HBeAg-negative chimpanzees (88A010, 95A008, and 95A010) was evaluated for HBV gene expression by RT-qPCR with probe sets in core to measure the amount of precore mRNA/pgRNA and in X to measure total HBV mRNA. (A) Mean total HBV mRNA amounts were compared between HBeAg-positive and HBeAg-negative chimpanzees before study, after the NUC lead-in (day 1), and 1 week after the second ARC-520 injection (day 36). (B) The numbers of total HBV transcripts and precore/pgRNA transcripts on day 1 are compared for the HBeAg-positive and HBeAg-negative chimpanzees. Error bars show SEM. Christine I. Wooddell et al., Sci Transl Med 2017;9:eaan0241 Published by AAAS

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