1. Lipogenic genes and SREBP1 protein are upregulated in HF‐R
Lipogenic genes and SREBP1 protein are upregulated in HF‐R Hepatic expression of lipogenic genes in recipients (n = 5–12 per group, per time point, two‐way ANOVA, post hoc Holm–Sidak comparisons, *P < 0.05). Error bars represent SEM.Immunoblot analysis of cleaved SREBP1 in the nuclear fraction. Representative image of two different sets of samples. On the right, quantification of SREBP1 normalized to p84.An example of connection between fatty acid synthesis pathway and metabolites depicted in Fig 2E.Hepatic gene expression in HFD‐fed animals. Hepatic Acot2 and Pltp transcript levels in mice fed HFD or CC for 10 weeks (n = 5 per group, per ZT, two‐way ANOVA, post hoc Holm–Sidak comparisons, *P < 0.05, **P < 0.01). Error bars represent SEM.Hepatic gene expression of PPARγ target genes in germ‐free mice fecal transplanted with microbiota from CC‐fed donor (GF‐CCR), HFD‐fed donor (GF‐HFR), and non‐treated germ‐free mice (n = 4–5 per each group, unpaired, two‐tailed Student's t‐test, *P < 0.05). Error bars represent SEM.
Mari Murakami et al. EMBO Rep. 2016;embr
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