1. Figure 2: How the MetO-rich protein immunization helps the clearance of toxic amyloid beta?
Amyloid-beta circulates in blood and brain
-Forcing the host immune system to
produce antibodies against MetO-
containing proteins, including:
MetO-beta amyloid.
Oxidative stress or
Aging
The Vaccine: a non-toxic MetO-rich protein
MetO-beta amyloid
Amyloid beta is being oxidized first
in its Met residue: yielding
a MetO Amyloid beta
Formation of soluble
toxic MetO-amyloid-beta aggregates
These antibody- MetO-beta amyloid
complexes are cleared from the system
By macrophages (“packman” –like cells)