1. Chapter 5: Renal Allograft Biopsy Wong Hin Seng

2. Table 5.2.1: Number of renal allograft biopsy, 2004-2010
Year
2004
2005
2006
2007
2008
2009
2010
Total
Number of renal transplant biopsy 52 71
118
124
133
180
802
4th MRRB report 2010, Malaysia

3. Figure 5.2.1: Number of renal allograft biopsy, 2004-201020 40 60 80
100
120
140
160
180
200
2004
2005
2006
2007
2008
2009
2010
Year
Number of renal transplant biopsy
Allograft biospy
4th MRRB report 2010, Malaysia

4. Table 5.2.2: Number of renal allograft biopsy by centre, 2004-2010
4th MRRB report 2010, Malaysia

5. 4th MRRB report 2010, Malaysia
Table 5.2.3: Renal allograft biopsy by year and age group, rate per million population,
Age
group
2004
2005
2006
2007 n %
Rate
<15 3
5.8
0.0 6
5.1
0.1 7
5.6
15-<25 14
26.9
0.3 15
21.1 25
21.2
0.5 19
15.3
0.4
25-<35
28.8 11
15.5
0.2
0.6
12.1
35-<45 23
32.4 26
22.0
0.7 49
39.5
1.2
45-<55 5
9.6 12
16.9 24
20.3
0.8
19.4
55-<65 1
1.9 8
11.3
6.8 10
8.1
>65 2
2.8 4
3.4
Total 52
100 71
118
124
4th MRRB report 2010, Malaysia

6. 4th MRRB report 2010, Malaysia
Continue;
Age
group
2008
2009
2010
Total n %
Rate
<15 9
7.3
0.1
6.8 8
4.4 42
5.2
15-<25 22
17.7
0.4 17
12.8
0.3 21
11.7
133
16.6
25-<35 20
16.1 30
22.6
0.6 29
145
18.1
0.5
35-<45 25
20.2 24 18 66
36.7
1.6
227
28.3
0.8
45-<55 35
28.2
1.1 36
27.1 40
22.2
1.2
176
21.9
0.9
55-<65 16 12
6.7 64
>65 4
3.2 1
2.2 15
1.9
0.2
124
100
180
802
4th MRRB report 2010, Malaysia

7. 4th MRRB report 2010, Malaysia
Figure 5.2.3: Renal allograft biopsy by year and age group, rate per million population,
0.2
0.4
0.6
0.8 1
1.2
1.4
1.6
1.8
2004
2005
2006
2007
2008
2009
2010
Year
Rate (Per million population)
<15
15-<25
25-<35
35-<45
45-<55
55-<65
>65
4th MRRB report 2010, Malaysia

8. Table 5.3: Indications for renal allograft biopsy, 2004-2010
* Patients may have one or more clinical presentation
* 48 patients have no information on clinical presentation (neither urine abnormalities nor graft function)
For 2004, 1 patient has 2 indications
For 2006, 4 patients have 2 indications
For 2007, 5 patients have 2 indications
For 2008, 6 patients have 2 indications
For 2009, 11 patients have 2 indications
For 2010, 7 patients have 2 indications
4th MRRB report 2010, Malaysia

9. >1 yr post transplant 4th MRRB report 2010, Malaysia
Table 5.4: Timing of renal allograft biopsy, (dates: date of biopsy & date of transplant)
Timing of renal transplant biopsy
Within 1 week
>1 week to 1month
> 1month to 3 months
> 3 months to 6 months
> 6months to 1 year
>1 yr post transplant
Total n %
2004 2
3.8 9
17.3 12
23.1 8
15.4 3
5.8 18
34.6 52
100
2005 1
1.4
12.7
11.3
16.9 6
8.5 35
49.3 71
2006 4
3.4 15 13
11.0
7.6 68
57.6
118
2007 5
4.0 14
12.1 10
8.1
6.5 72
58.1
124
2008
4.8
10.5 17
13.7 11
8.9 69
55.6
2009 20
15.0
6.0
4.5 79
59.4
133
2010
3.3 40
22.2 28
15.6 21
11.7
7.2
40.0
180 29
3.6
115
14.3
113
14.1 76
9.5 56
7.0
413
51.5
802
4th MRRB report 2010, Malaysia

10. Figure 5.4: Timing of renal allograft biopsy, 2004-201010 20 30 40 50 60 70 80 90
2004
2005
2006
2007
2008
2009
2010
Year
NUmber of timing of graft biopsy
Within 1 week
>1 week to 1month
> 1month to 3 months
> 3 months to 6 months
> 6months to 1 year
>1 yr post transplant
4th MRRB report 2010, Malaysia

11. 4th MRRB report 2010, Malaysia
Table 5.5.1: Biopsy method,
*No data on biopsy technique
4th MRRB report 2010, Malaysia

12. Figure 5.5.1: Biopsy method (censored for missing data), 2004-2010
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
2004
2005
2006
2007
2008
2009
2010
Year
Propotion of biopsy method
Blind Not US guided
US guided: Real time
US guided: Not real-time
4th MRRB report 2010, Malaysia

13. Table 5.5.2: Number of passes, 2004-2011
4th MRRB report 2010, Malaysia

14. Figure 5.5.2: Number of passes, 2004-201110 20 30 40 50 60 70
2004
2005
2006
2007
2008
2009
2010
Year
Percentage (%) 1 2 3 4 5 6
4th MRRB report 2010, Malaysia

15. Table 5.5.3: Number of glomeruli obtained on biopsy, 2004-2010
* No data information on the number of glomeruli
4th MRRB report 2010, Malaysia

16. Figure 5.5.3: Number of glomeruli obtained on biopsy, 2004-201010 20 30 40 50 60
2004
2005
2006
2007
2008
2009
2010
Year
Percentage (%)
1-9
10-19
>20
Missing/Unknown*
4th MRRB report 2010, Malaysia

17. Table 5.5.4: Type of complications, 2004-2011
a Mild complication is defined as presence of gross hematuria, perirenal collection, hematoma, or AVM that do not require intervention
b Severe complication is defined as presence of hypotension or complications requiring intervention.
c No data information for complications
4th MRRB report 2010, Malaysia

18. Figure 5.6: Histological diagnosis, 2004-201010 20 30 40 50 60
2004
2005
2006
2007
2008
2009
2010
Year
Percentage(%)
Acute rejection
Borderline rejection
Calcineurin inhibitor toxicity
Chronic allograft nephropathy
Acute tubular necrosis
PTLD**
De novo
Recurrent GN
Diabetic nephropathy
Others
4th MRRB report 2010, Malaysia

19. Table 5.6 Histological diagnosis, 2004-2010
* Patients may have more than 1 diagnosis classification
**Post Transplant Lymphoproliferative disease
4th MRRB report 2010, Malaysia