1. Chapter 11 Paediatrics 2014 ANZDATA Registry 37th Annual Report Data to 31-Dec-2013 ANZDATA gratefully acknowledges the contributions of the Paediatric Working Group convened by Dr Sean Kennedy

2. 2014 ANZDATA Registry 37 th Annual Report

6. Primary renal disease, incident patients Australia and New Zealand 2008-2013 Primary Renal Disease0-45-1010-1415-17Total GN8 (9%)20 (27%)25 (26%)37 (36%)90 (25%) - FSGS1 (1%)8 (11%)7 (7%)6 (6%)22 (6%) Familial GN3 (4%)-2 (2%)3 (3%)8 (2%) Reflux Nephropathy4 (5%)3 (4%)7 (7%)9 (9%)23 (6%) Polycystic Kidney Disease5 (6%)4 (5%)2 (2%)4 (4%)15 (4%) Medullary Cystic Disease-2 (3%)5 (5%)2 (2%)9 (3%) Posterior Urethral Valve10 (12%)1 (1%)13 (14%)2 (2%)26 (7%) Haemolytic Uraemic Syndrome6 (7%)1 (1%) 2 (2%)10 (3%) Hypoplasia/Dysplasia26 (31%)16 (22%)12 (13%)10 (10%)64 (18%) Diabetes--1 (1%) 2 (1%) Cortical Necrosis2 (2%)3 (4%)2 (2%)3 (3%)10 (3%) Interstitial Nephritis-1 (1%) -2 (1%) Cystinosis-1 (1%) -2 (1%) Uncertain-2 (3%)-4 (4%)6 (2%) Misc/Other20 (24%)11 (15%)17 (18%)19 (19%)67 (19%) Total857396102334

7. 2014 ANZDATA Registry 37 th Annual Report Modality of Initial Renal Replacement Therapy By Year of First Treatment, Australia and New Zealand Age Group200820092010201120122013Total 0-9 Years2327222924 149 - HD6 (26%)4 (15%)5 (23%)10 (34%)8 (33%)6 (25%)39 (26%) - PD15 (65%)17 (63%)14 (64%)14 (48%)12 (50%)16 (67%)88 (59%) - Transplant2 (9%)6 (22%)3 (14%)5 (17%)4 (17%)2 (8%)22 (15%) 10-17 Years382725263930185 - HD22 (58%)12 (44%)13 (52%)8 (31%)16 (41%)12 (40%)83 (45%) - PD8 (21%)12 (44%)5 (20%)12 (46%)15 (38%)12 (40%)64 (35%) - Transplant8 (21%)3 (11%)7 (28%)6 (23%)8 (21%)6 (20%)38 (21%) Total615447556354334

8. 2014 ANZDATA Registry 37 th Annual Report Modality of Prevalent Patients By Year of Treatment, Australia and New Zealand Current Treatment 200820092010201120122013Total HD35 (11%)29 (9%)30 (9%)29 (9%)30 (8%) 183 (9%) PD54 (17%)57 (18%)50 (15%)53 (16%)49 (14%)46 (13%)309 (16%) Transplant225 (72%)229 (73%)244 (75%)250 (75%)274 (78%)277 (78%)1499 (75%) Total314315324332353 1991

9. 2014 ANZDATA Registry 37 th Annual Report

13. Graft Numbers 2004 - 2013 Australia and New Zealand Graft Number 2004200520062007200820092010201120122013 135472628453640445543 24143433215

14. 2014 ANZDATA Registry 37 th Annual Report Donor Source by Year 2004 - 2015, Number (% of Transplants) Donor Type2004200520062007200820092010201120122013 LD pre-emptive5 (13%)10 (21%)7 (23%)8 (26%)9 (18%)9 (23%)10 (23%)10 (22%)12 (21%)8 (17%) LD not pre-emptive19 (49%)20 (42%)15 (50%)13 (42%)24 (49%)16 (41%)19 (44%)10 (22%)26 (46%)20 (42%) DBD15 (38%)17 (35%)8 (27%)9 (29%)13 (27%)12 (31%)11 (26%)21 (46%)17 (30%)18 (38%) DCD0 (0%)1 (2%)0 (0%)1 (3%)3 (6%)2 (5%)3 (7%)5 (11%)1 (2%)2 (4%) Total39483031493943465648

15. 2014 ANZDATA Registry 37 th Annual Report Antibody Use for Induction Immunosuppression, Number receiving (%) CountryType of Agent20092010201120122013 Australia Intravenous immunoglobulin1 (2.9%)0 (0.0%)2 (4.8%)0 (0.0%)2 (4.7%) Anti-CD2533 (97.1%)35 (92.1%)37 (88.1%)41 (89.1%)36 (83.7%) Rituximab0 (0.0%)1 (2.6%)0 (0.0%) T cell depleting polyclonal Ab1 (2.9%)2 (5.3%)2 (4.8%)1 (2.2%)1 (2.3%) Total new transplants3438424643 New Zealand Intravenous immunoglobulin0 (0.0%) 1 (10.0%)0 (0.0%) Anti-CD250 (0.0%)1 (20.0%)4 (100.0%)10 (100.0%)4 (80.0%) Rituximab0 (0.0%) 1 (20.0%) T cell depleting polyclonal Ab0 (0.0%) Total new transplants554105

16. 2014 ANZDATA Registry 37 th Annual Report

25. Patient and Graft Survival, Paediatric Transplant Recipients 2004 - 2013 (95% CI) OutcomeTransplant year (N)6 months1 year3 years5 years Patient 2004-05 (n=87)10099 (92-100)98 (91-99)96 (89-99) 2006-07 (n=61)100 98 (89-100) 2008-09 (n=88)100 2010-11 (n=89)10099 (92-100) - 2012-13 (n=104)99 (91-100) -- Graft 2004-05 (n=87)97 (90-99)95 (88-98)88 (79-94)76 (66-84) 2006-07 (n=61)93 (83-97)90 (79-95)82 (70-90)79 (66-87) 2008-09 (n=88)94 (87-98) 87 (78-93)84 (74-90) 2010-11 (n=89)10098 (91-99)96 (88-98)- 2012-13 (n=104)99 (91-100)97 (90-99)--

26. 2014 ANZDATA Registry 37 th Annual Report Cause of Graft Loss, Transplants Performed 2004-2013 by Age at Transplant Cause of Graft Loss0-45-910-1415-17Total Death with function02125 Acute rejection12159 Chronic allograft nephropathy1310923 Vascular21238 Technical00112 Glomerulonephritis02417 Non-compliance00044 Other11327 Total511222765

27. 2014 ANZDATA Registry 37 th Annual Report Cause of Graft Loss, Transplants Performed 2004-2013 by Age at Graft Loss Cause of Graft Loss0-45-910-1415-17Total Death with function01045 Acute rejection03047 Chronic allograft nephropathy0031417 Vascular20338 Technical00112 Glomerulonephritis01416 Non-compliance00022 Other01326 Total26143153

28. 2014 ANZDATA Registry 37 th Annual Report

30. Type of Rejection Timing of Rejection Type of Rejection 200420052006200720082009201020112012 <6 months No biopsy256201320 Cellular562462332 ABMR000000100 Cellular + ABMR 1 010010000 6-24 months No biopsy3310101-- Cellular25141236-- ABMR0001000-- Cellular + ABMR 1 0000102--