1. Baseline Characteristics of the Study Cohort*
Zethelius B, et al. N Engl J Med 2008;358:

2. Hazard Ratios for Death from All Causes and from Cardiovascular Causes, According to Biomarker Levels*
* Values were calculated with the use of multivariable Cox regression analysis. Data were adjusted for the following variables: age at baseline (continuous), systolic blood pressure (continuous), use or nonuse of antihypertensive treatment (binary), total cholesterol (continuous), highdensity lipoprotein cholesterol (continuous), use or nonuse of lipidlowering treatment (binary), presence or absence of diabetes (binary), smoking status (binary), and bodymass index (continuous). CVD denotes cardiovascular disease, and NTproBNP Nterminal pro–brain natriuretic peptide.
† This is the cutoff point that has been suggested in the literature.
‡ This cutoff point has been identified for optimized discrimination in the present study.
Zethelius B, et al. NEJM 2008;358:

3. C Statistic for Cox Regression Models Predicting Death from Cardiovascular Causes and from All Causes in the Whole Sample and in the Subsample without Cardiovascular Disease at Baseline*
Zethelius B, et al. N Engl J Med 2008;358:

4. Reclassification of Participants without Cardiovascular Disease at Baseline Who Died from Cardiovascular Causes or Who Did Not Die*
Zethelius B, et al. N Engl J Med 2008;358: