1. Review JEOPARDY! History DNA structure Replication Transcription
Translation
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2. $100 Who is Maurice Wilkins, Francis Crick, and James Watson?
History
These 3 individuals won the Nobel Prize in 1962 for their discoveries concerning the molecular structure of nucleic acids in DNA and its significance for information transfer.
Who is Maurice Wilkins, Francis Crick, and James Watson?
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3. History
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In what year did Watson and Crick publish their findings for the structure of DNA?
What is 1953?
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4. History
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This scientist produced an x-ray crystallography image that lead to the structure of DNA .
Who is Rosalind Franklin?
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5. $400 Photo 51 revealed _____& _______in regards to the DNA molecule
History
Photo 51 revealed _____& _______in regards to the DNA molecule
What is helical shape and diameter of the molecule?
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6. $500 It was over these 13 years that Human Genome was first sequenced.
History
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It was over these 13 years that Human Genome was first sequenced.
What is ?
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7. $100 DNA’s backbone consists of these two components (be specific).
What are deoxyribose sugar and a phosphate group?
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8. $200 The sequence of these 4 bases determine our genetic code.
DNA
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The sequence of these 4 bases determine our genetic code.
What are adenine, guanine, cytosine and thymine?
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9. $300
DNA
This bond occurs between the 3’ carbon sugar of one nucleotide and the phosphate group of another nucleotide.
What is phosphodiester bond?
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10. $400
DNA
These two elements are attracted to each other creating two hydrogen bonds between adenine and thymine.
Also, why is the phosphate group located on the outside of the molecule?
What are hydrogen (slightly positive) and nitrogen (slightly negative)?
What is hydrophilic?
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11. $500
DNA
This is another name for the double ring nitrogenous bases (also include the names of each double ring).
What are Purines (adenine and guanine)?
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12. Replication
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This is the enzyme that breaks the hydrogen bonds between the two DNA parent strands.
What is helicase?
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13. $200 This is the enzyme used to elongate a strand of DNA.
Replication
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This is the enzyme used to elongate a strand of DNA.
What is DNA polymerase III?
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14. Replication
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This information lead to the conclusion that purines must pair with pyrimidines and this lead to complementary base pairing and that DNA had a mechanism for replicating.
What is the width of 20 Angstroms (determined by x-ray crystallography?
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15. $400
Replication
The basis for the difference in how the leading and lagging strand are synthesized.
What is DNA polymerase can only add new nucleotides to the 3’ end of a growing strand (thus it goes in the 5’ 3’ direction only)?
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16. $500
Replication
A biochemist isolated, purified, and combined in a test tube a variety of molecules needed for DNA replication. When she added some DNA to the mixture replication occurred but each DNA molecule consisted of a normal strand paired with numerous segments of DNA a few hundred nucleotides long. This is the enzyme she forgot in her experiment.
What is DNA ligase?
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17. $100 This is the main purpose of transcription.
What is copying a gene from DNA to an mRNA strand?
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18. $200 This DNA template 3’ AATGCAT 5’ codes for this mRNA sequence.
Transcription
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This DNA template 3’ AATGCAT 5’ codes for this mRNA sequence.
What is 5’ UUACGUA 3’?
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19. $300 This enzyme catalyzes the linkage between ribonucleotides.
Transcription
This enzyme catalyzes the linkage between ribonucleotides.
What is RNA polymerase?
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20. $400
Transcription
In order for transcription to occur, there has to be a specific recognition sequence.
What is the promoter?
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21. $500
Transcription
DAILY DOUBLE!
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22. Transcription
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Including these three steps in transcription and before the mRNA leaves the nucleus these are removed .
What is initiation, elongation, and termination? What are introns?
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23. $100 The structure of tRNA has two important features.
Translation
The structure of tRNA has two important features.
What is the anticodon and the site for the amino acid?
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24. $200 This organelle is primarily responsible for protein synthesis.
Translation
This organelle is primarily responsible for protein synthesis.
What are ribosomes?
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25. $300 The P site of a ribosome is where this occurs.
Translation
The P site of a ribosome is where this occurs.
What is holding the tRNA containing the growing polypeptide chain?
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26. $400
Translation
This specific mutation could result in a much shorter polypeptide chain.
What is a nonsense base substitution?
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27. $500
Translation
This is the first amino acid inserted into a new polypeptide chain.
What is methionine?
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