1. کزین برتر اندیشه بر نگذرد
بنام خداوند جان و خرد
کزین برتر اندیشه بر نگذرد

2. IRAN UNIVERSITY OF MEDICAL SCIENCE NEONATAL HEMATOLOGY CONGRESS
Dr FARHAD CHOOBDAR
NEONATALOGIST
IRAN UNIVERSITY OF MEDICAL SCIENCE
NEONATAL HEMATOLOGY CONGRESS

3. FRESH FROZEN PLASMA & CRYOPRECIPITATE

5. Fresh Frozen Plasma Plasma extract from Human blood
Stored frozen at -18 to -30⁰c up to 1 year
Thawed plasma can be stored at 1-6⁰c up to 5 days
Thawed plasma should be used during 4h

6. Indications Deficiency of coagulation factor Liver dysfunction DIC
Massive Transfusion
Reversal of Warfarin effect
HUS
Purpura Fulminance

7. Not Indicated As: Volume expander Immunoglobulin replacement
Nutritional support
Wound healing
Therapy for sepsis
Instead of Factor concentrate
Prophylaxy of IVH in preterms

8. How To Order FFP should be ABO-compatible
Don’t need to be Rh-compatible
Don’t need to screen for CMV or HIV
Don’t need to be leukoreduced
Don’t need to Irradiate

9. ABO selection of blood component
Patient ABO type
RBC & PLATELET
FFP & CRYO O
O,A,B,AB A
A,O
A,AB B
B,O
B,AB AB
AB,A,B,O

10. How to infused Total infusion: Up to 10-20 ml/kg/day
Infusion rate : 1-3 ml/kg/h
Not to be given by long line
Can be given via UVC & UAC
Can be given via peripheral or central line

11. Complications Anaphylactic reaction in IgA deficient patients
Transfusion Related Acute lung injury(TRALI)
(Ab mediated)
Volume overload

12. Cryoprecipitate Cold-insoluble precipitate Prepared from thawed FFP
Re-frozen at -18⁰c
Shelf life about 1 year

13. Cryoprecipitate Contain factors I-VIII-XIII & vWF & Fibronectin
Each unit about ml
80 units factor VIII
150 mg fibrinogen

14. Usage Congenital or Acquired deficiency of Fibrinogen
Instead of factor VIII in emergency
Deficiency of factor XIII
DIC

15. Dosage & complication Dosage: 1 unite/5 kg Bw Same as FFP Anaphylaxis
TRALI

16. 1