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Hiroki Sato, James E Jordan, Zhi-Qing Zhao, S

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Presentation on theme: "Hiroki Sato, James E Jordan, Zhi-Qing Zhao, S"— Presentation transcript:

1 Gradual Reperfusion Reduces Infarct Size and Endothelial Injury but Augments Neutrophil Accumulation 
Hiroki Sato, James E Jordan, Zhi-Qing Zhao, S.S Sarvotham, Jakob Vinten-Johansen  The Annals of Thoracic Surgery  Volume 64, Issue 4, Pages (October 1997) DOI: /S (97)

2 Fig. 1 Mean left anterior descending (LAD) coronary artery blood flow (mL/min) through the carotid–LAD shunt during the course of the experiment. (Cntl = control; Isch = ischemia; open boxes = abrupt group; filled circles = ramped reperfusion group; ∗p < 0.05 versus abrupt group.) The Annals of Thoracic Surgery  , DOI: ( /S (97) )

3 Fig. 2 (A) Segmental work in the area at risk during baseline (cntl), ischemia (Isch), and 15, 60, 120, and 180 minutes of reperfusion. All data at the ischemia and reperfusion time points were different from their respective group baseline value. (B) The modulus of segmental diastolic stiffness determined as the curvature of the exponential end-diastolic pressure-length relationship during transient bicaval occlusion. The modulus of stiffness (β coefficient) is a unitless number. There were no group differences. The Annals of Thoracic Surgery  , DOI: ( /S (97) )

4 Fig. 3 (A) Size of the area at risk (AAR) relative to the left ventricular mass and infarct size represented as area of necrosis (AN) relative to the AAR (AN/AAR) and left ventricle (AN/LV). (B) Total plasma creatine kinase (CK) levels expressed as international units (IU) per gram of protein during the course of the experiment. (∗p < 0.05 versus abrupt group; abbreviations are as in Fig. 1.) The Annals of Thoracic Surgery  , DOI: ( /S (97) )

5 Fig. 4 Myeloperoxidase (MPO) activity in units per gram tissue in the nonischemic zone (NIZ), the nonnecrotic ischemic zone (IZ), and the necrotic ischemic zone (NEC). (∗p < 0.05 versus abrupt group.) The Annals of Thoracic Surgery  , DOI: ( /S (97) )

6 Fig. 5 Concentration-response curves of left anterior descending coronary artery segments to acetylcholine (A), the calcium ionophore A23187 (B), and the smooth muscle relaxing agent, acidified NaNO2 (C). (∗p < 0.05 abrupt or ramp group versus control; ∗∗p < 0.05 abrupt group versus ramp group; †p < 0.05 versus previous time point.) The Annals of Thoracic Surgery  , DOI: ( /S (97) )

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