1. Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization 
Robert D. Riley, MD, Hiroki Sato, MD, PhD, Zhi-Qing Zhao, MD, PhD, Vinod H. Thourani, MD, James E. Jordan, BS, Adolfo X. Fernandez, BS, Xin-Liang Ma, MD, PhD, Duncan R. Hite, MD, Dean F. Rigel, PhD, Theodore C. Pellas, VMD, PhD, Jane Peppard, PhD, Kurt A. Bill, PhD, Rodney W. Lappe, PhD, Jakob Vinten-Johansen, PhD 
The Journal of Thoracic and Cardiovascular Surgery 
Volume 120, Issue 2, Pages (August 2000)
DOI: /mtc
Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

2. Fig. 1
A, Superoxide radical generation by porcine PMNs stimulated by increasing concentrations of rhC5a. B, Concentration responses of C5a-stimulated superoxide radical generation by porcine PMNs and increasing concentrations of CGS *P <.05 versus control.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc )
Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

3. Fig. 2
A, Stimulation of porcine PMN adherence to porcine coronary artery endothelium by increasing concentrations of rhC5a. B, Inhibition by CGS on adherence of C5a-stimulated porcine PMNs to unstimulated coronary artery endothelium. C5a, PMN stimulated with 100 nmol/L rhC5a, no treatment. *P <.05 versus control.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc )
Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

4. Fig. 3
Segmental shortening in the ischemia-reperfusion AAR (A) and in the nonischemic zone (B) during the course of the experiment. SAL, Saline solution group; MANN/BUFF, mannitol-buffer vehicle group; CGS, CGS group; CNTL, control or baseline; ISCH, coronary occlusion; BW30, BW60, and BW120, minutes after discontinuation of cardiopulmonary bypass. *P <.05 versus the saline solution and mannitol-buffer vehicle groups.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc )
Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

5. Fig. 4
Infarct size data as a percentage of either LV mass (in grams) or AAR. A, AAR normalized for mass of the LV; B, area of necrosis (An ) normalized for LV mass; C, area of necrosis normalized for AAR. Open bar, Saline solution group; gray bar, mannitol-buffer group; black bar, CGS group. *P <.05 versus the saline solution and mannitol-buffer vehicle groups.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc )
Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions