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Fig. 1. Serum HBsAg, HBcrAg, and HBeAg reduction in human patients treated with a single dose of ARC-520. Serum HBsAg, HBcrAg, and HBeAg reduction in human.

Published byYulia Sanjaya Modified over 5 years ago

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Presentation on theme: "Fig. 1. Serum HBsAg, HBcrAg, and HBeAg reduction in human patients treated with a single dose of ARC-520. Serum HBsAg, HBcrAg, and HBeAg reduction in human."— Presentation transcript:

1 Fig. 1. Serum HBsAg, HBcrAg, and HBeAg reduction in human patients treated with a single dose of ARC-520. Serum HBsAg, HBcrAg, and HBeAg reduction in human patients treated with a single dose of ARC-520. CHB patients were given a single intravenous dose of ARC-520 (1 to 4 mg/kg) on a background of daily oral NUCs. HBsAg (A) or HBcrAg (C) reduction in CHB patients who were NUC-experienced HBeAg-negative and received single doses (1 to 4 mg/kg) (cohorts 1 to 4, n = 6). (B) HBsAg reduction in CHB patients who were NUC-experienced HBeAg-negative (cohort 4, n = 6) or NUC-experienced HBeAg-positive (cohort 5, n = 6) who received a single dose (4 mg/kg). (D) HBcrAg and HBeAg reduction in CHB patients who were NUC-experienced HBeAg-positive and received a single dose (4 mg/kg) (cohort 5, n = 6). (E) HBsAg reduction for individual CHB patients who were NUC-naïve HBeAg-positive and received a single dose (4 mg/kg) in cohort 7 (n = 6). (F) HBsAg, HBeAg, and HBcrAg reductions in CHB patients who were NUC-naïve HBeAg-positive and received a single dose (4 mg/kg) (cohort 7, n = 5). (G) HBsAg reduction in CHB patients who were HBeAg-negative and NUC-naïve (cohort 7, n = 6) or NUC-experienced (cohort 4, n = 6). PBO, patients on NUC therapy given placebo injection. Error bars show SEM. Christine I. Wooddell et al., Sci Transl Med 2017;9:eaan0241 Published by AAAS

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