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Superiority of magnesium cardioplegia in neonatal myocardial protection  Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

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Presentation on theme: "Superiority of magnesium cardioplegia in neonatal myocardial protection  Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,"— Presentation transcript:

1 Superiority of magnesium cardioplegia in neonatal myocardial protection 
Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson, MD, Shaikh Rahman, PhD, Gerald D Buckberg, MD, Tingrong Wang, MD, Michel N Ilbawi, MD  The Annals of Thoracic Surgery  Volume 68, Issue 6, Pages (December 1999) DOI: /S (99)01142-X

2 Fig 1 Left ventricular systolic function as measured by the end systolic elastance (EES) and expressed as percent of recovery of baseline values. Hearts protected with a hypocalcemic cardioplegic solution alone exhibited marked loss of systolic function. In contrast, there is complete preservation of systolic function when magnesium is added to hypocalcemic cardioplegic solution. However, magnesium enrichment was not able to offset the detrimental effects of a normocalcemic cardioplegic solution, resulting in diminished systolic function. ∗p < The Annals of Thoracic Surgery  , DOI: ( /S (99)01142-X)

3 Fig 2 Left ventricular diastolic compliance as measured by the end diastolic pressure–volume relationship, and expressed as a percentage of stiffness compared to baseline values. There is a marked increase in diastolic stiffness in hearts protected with a hypocalcemic cardioplegic solution without magnesium. In contrast, there is only a minimal increase in diastolic stiffness in hearts protected with a magnesium enriched hypocalcemic cardioplegic solution. However, this improvement is negated when magnesium is added to a normocalcemic cardioplegic solution. ∗p < The Annals of Thoracic Surgery  , DOI: ( /S (99)01142-X)

4 Fig 3 Overall left ventricular myocardial function measured by preload recruitable stroke work (PRSW) and expressed as percent recovery compared to baseline values. ∗p < The Annals of Thoracic Surgery  , DOI: ( /S (99)01142-X)

5 Fig 4 Coronary vascular resistance (CVR) measured during each cardioplegic infusion, once the pressure and flow were stable. (See text for details.) ∗p < The Annals of Thoracic Surgery  , DOI: ( /S (99)01142-X)

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