Presentation is loading. Please wait.

Presentation is loading. Please wait.

Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung  Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,

Published byTrịnh Ngô Modified over 5 years ago

Similar presentations

Presentation on theme: "Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung  Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,"— Presentation transcript:

1 Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung 
Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida, MD, Masao Inoue, MD, Takahiro Sawada, MD, Takeshi Nagayasu, MD, Tadayuki Oka, MD  The Annals of Thoracic Surgery  Volume 78, Issue 1, Pages (July 2004) DOI: /j.athoracsur

2 Fig 1 Mean pulmonary arterial pressure. Data are shown as mean ± SD (*p < 0.05 versus control group). Circles = sham; squares = controls; diamonds = nitric oxide inhalation. (min. = minutes; pre = prereperfusion.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

3 Fig 2 Arterial oxygen tension (Pao2). Data are shown as mean ± SD (*p < 0.05 versus control group). Circles = sham; squares = controls; diamonds = nitric oxide inhalation. (min. = minutes; pre = prereperfusion.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

4 Fig 3 Lung wet-to-dry weight ratio after 120 minutes of reperfusion. Data are shown as mean ± SD. (NO = nitric oxide.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

5 Fig 4 Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) staining after ischemia-reperfusion: (a) prereperfusion; (b) 15 minutes after reperfusion; (c) 30 minutes after reperfusion; (d) 60 minutes after reperfusion; (e) 120 minutes after reperfusion; (f) quantification of TUNEL-positive cells at prereperfusion (pre) or after 15, 30, 60, and 120 minutes of reperfusion. Date are shown as mean ± SD (*p < 0.05 versus prereperfusion). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

6 Fig 5 Hematoxylin & eosin (HE) staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) staining after 120 minutes of reperfusion. (a–c) HE staining; (d–f) TUNEL staining. (a) and (d) are the sham group; (b) and (e) are the control group; (c) and (f) are the inhaled nitric oxide group. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

7 Fig 6 Quantification of terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL)-positive cells after 120 minutes of reperfusion. Data are shown as mean ± SD. Inhaled nitric oxide (NO) reduced the increase in TUNEL-positive cells compared with controls. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur )

Download ppt "Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung  Hideki Yamashita, MD, Shinji Akamine, MD, Yorihisa Sumida,"

Similar presentations

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.
Aprotinin improves pulmonary function during reperfusion in an isolated lung model  Menen A Mathias, MD, Curtis G Tribble, MD, Jeffrey F Dietz, BS, Richard.

Aprotinin improves pulmonary function during reperfusion in an isolated lung model  Menen A Mathias, MD, Curtis G Tribble, MD, Jeffrey F Dietz, BS, Richard.
Cardiomyocyte Apoptosis After Antegrade and Retrograde Cardioplegia During Aortic Valve Surgery  Tommi Vähäsilta, MD, PhD, Markus Malmberg, MD, Antti.

Cardiomyocyte Apoptosis After Antegrade and Retrograde Cardioplegia During Aortic Valve Surgery  Tommi Vähäsilta, MD, PhD, Markus Malmberg, MD, Antti.
Mauer Biscotti, MD, Matthew Bacchetta, MD 

Mauer Biscotti, MD, Matthew Bacchetta, MD 
Inhaled nitric oxide reduces human lung allograft dysfunction

Inhaled nitric oxide reduces human lung allograft dysfunction
Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin  Pedro Reck dos Santos, MD, MS, Jin Sakamoto, MD, Manyin.

Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin  Pedro Reck dos Santos, MD, MS, Jin Sakamoto, MD, Manyin.
Successful Lung Transplantation for Pulmonary Disease Associated With Erdheim– Chester Disease  Kohei Hashimoto, MD, Kentaroh Miyoshi, MD, Hisao Mizutani,

Successful Lung Transplantation for Pulmonary Disease Associated With Erdheim– Chester Disease  Kohei Hashimoto, MD, Kentaroh Miyoshi, MD, Hisao Mizutani,
Mary E. Huerter, MD, MA, Ashish K

Mary E. Huerter, MD, MA, Ashish K
Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C

Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C
High basal level of autophagy in high-altitude residents attenuates myocardial ischemia– reperfusion injury  Yijie Hu, MD, Qi Sun, MD, Zhiping Li, MD,

High basal level of autophagy in high-altitude residents attenuates myocardial ischemia– reperfusion injury  Yijie Hu, MD, Qi Sun, MD, Zhiping Li, MD,
Adenosine-enhanced ischemic preconditioning modulates necrosis and apoptosis: effects of stunning and ischemia–reperfusion  Bradford Stadler, BS, Jonathan.

Adenosine-enhanced ischemic preconditioning modulates necrosis and apoptosis: effects of stunning and ischemia–reperfusion  Bradford Stadler, BS, Jonathan.
Keiji Ohata, MD, Toyofumi F

Keiji Ohata, MD, Toyofumi F
Gene transfer of heat shock protein 70 protects lung grafts from ischemia-reperfusion injury  Masafumi Hiratsuka, MD, Bassem N Mora, MD, Motoki Yano,

Gene transfer of heat shock protein 70 protects lung grafts from ischemia-reperfusion injury  Masafumi Hiratsuka, MD, Bassem N Mora, MD, Motoki Yano,
Progressive thermopreconditioning attenuates rat cardiac ischemia/reperfusion injury by mitochondria-mediated antioxidant and antiapoptotic mechanisms 

Progressive thermopreconditioning attenuates rat cardiac ischemia/reperfusion injury by mitochondria-mediated antioxidant and antiapoptotic mechanisms 
Philip J Wolfson, MD  The Annals of Thoracic Surgery 

Philip J Wolfson, MD  The Annals of Thoracic Surgery 
Cardiomyocyte Apoptosis After Antegrade and Retrograde Cardioplegia During Aortic Valve Surgery  Tommi Vähäsilta, MD, PhD, Markus Malmberg, MD, Antti.

Cardiomyocyte Apoptosis After Antegrade and Retrograde Cardioplegia During Aortic Valve Surgery  Tommi Vähäsilta, MD, PhD, Markus Malmberg, MD, Antti.
Meena Nathan, MD, Ingeborg Friehs, MD, Yeong-Hoon Choi, MD, Douglas B

Meena Nathan, MD, Ingeborg Friehs, MD, Yeong-Hoon Choi, MD, Douglas B
Sodium nitroprusside mitigates oleic acid-induced acute lung injury

Sodium nitroprusside mitigates oleic acid-induced acute lung injury
Nathalie Roy, MD, Ingeborg Friehs, MD, Douglas B

Nathalie Roy, MD, Ingeborg Friehs, MD, Douglas B
Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Similar presentations

Ads by Google