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Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C

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Presentation on theme: "Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C"— Presentation transcript:

1 Glutamate Excitotoxicity Mediates Neuronal Apoptosis After Hypothermic Circulatory Arrest 
Elaine E. Tseng, MD, Malcolm V. Brock, MD, Mary S. Lange, MA, Juan C. Troncoso, MD, Mary E. Blue, PhD, Charles J. Lowenstein, MD, Michael V. Johnston, MD, William A. Baumgartner, MD  The Annals of Thoracic Surgery  Volume 89, Issue 2, Pages (February 2010) DOI: /j.athoracsur Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Intracerebral glutamate levels (μM) over time with and without MK-801 treatment (A). Intracerebral glycine levels (μM) (B) and intracerebral citrulline levels (μM) (C) over time with and without MK-801 treatment. (■ = HCA; □ = MK-801; * = p < 0.05 compared with baseline; ** = p < 0.05 compared with HCA without MK-801 treatment; CPB = cardiopulmonary bypass; HCA = hypothermic circulatory arrest). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Light microscopy of hematoxylin and eosin (H&E) stained sections for a normal dog (A). Apoptosis is seen in a hypothermic circulatory arrest (HCA) treated dog (B). Reduction in apoptosis seen in an MK-801-treated HCA dog shown by light microscopy of H&E stained sections (C). (Original magnification ×100.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate biotin nick end-labeling (TUNEL) assay shows no DNA fragmentation in a normal dog (A). The TUNEL demonstrates cells with DNA fragmentation in a hypothermic circulatory arrest (HCA) dog (B). Reduction in cells with DNA fragmentation is seen in an HCA dog treated with MK-801 (C). (Original magnification ×100.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

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