1. Variants Near FOXE1 Are Associated with Hypothyroidism and Other Thyroid Conditions: Using Electronic Medical Records for Genome- and Phenome-wide Studies 
Joshua C. Denny, Dana C. Crawford, Marylyn D. Ritchie, Suzette J. Bielinski, Melissa A. Basford, Yuki Bradford, High Seng Chai, Lisa Bastarache, Rebecca Zuvich, Peggy Peissig, David Carrell, Andrea H. Ramirez, Jyotishman Pathak, Russell A. Wilke, Luke Rasmussen, Xiaoming Wang, Jennifer A. Pacheco, Abel N. Kho, M. Geoffrey Hayes, Noah Weston, Martha Matsumoto, Peter A. Kopp, Katherine M. Newton, Gail P. Jarvik, Rongling Li, Teri A. Manolio, Iftikhar J. Kullo, Christopher G. Chute, Rex L. Chisholm, Eric B. Larson, Catherine A. McCarty, Daniel R. Masys, Dan M. Roden, Mariza de Andrade 
The American Journal of Human Genetics 
Volume 89, Issue 4, Pages (October 2011)
DOI: /j.ajhg
Copyright © 2011 The American Society of Human Genetics Terms and Conditions

2. Figure 1
Genome-wide Association Analysis of Individuals with Primary Hypothyroidism versus Controls
SNP tests of association (logistic regression) under the assumption of an additive genetic model adjusted for sex, birth decade, and study site; the tests incorporated 522,164 SNPs. The red horizontal line indicates p = 5 × 10−8, the threshold for genome-wide significance.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2011 The American Society of Human Genetics Terms and Conditions

3. Figure 2 Regional Associations Near FOXE1
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2011 The American Society of Human Genetics Terms and Conditions

4. Figure 3 Manhattan Plot of Phenome-wide Association Study for rs965513
The PheWAS considered 866 phenotypes via single SNP tests of association (logistic regression) adjusted for age and sex. The red line indicates Bonferroni significance for these associations, p = 5.8 × 10−5. The blue line indicates p = For labeled associations, the dot size varies by the magnitude of the odds ratio. For purposes of display, we normalized all odds ratios by taking the multiplicative absolute value such that all values were greater than 1 (e.g., an odds ratio of 0.5 becomes 2).
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2011 The American Society of Human Genetics Terms and Conditions