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A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval  Jong Wook Kim, Kyung-Won Hong, Min Jin Go, Sung Soo.

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Presentation on theme: "A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval  Jong Wook Kim, Kyung-Won Hong, Min Jin Go, Sung Soo."— Presentation transcript:

1 A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval 
Jong Wook Kim, Kyung-Won Hong, Min Jin Go, Sung Soo Kim, Yasuharu Tabara, Yoshikuni Kita, Takeshi Tanigawa, Yoon Shin Cho, Bok-Ghee Han, Bermseok Oh  The American Journal of Human Genetics  Volume 91, Issue 1, Pages (July 2012) DOI: /j.ajhg Copyright © 2012 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Manhattan Plot of Genome-wide Association Signals from Phase 1 Study The −log10(p) values are plotted against chromosomal base-pair positions. Pink labeling indicates previously reported loci for the QT interval, and green labeling indicates previously unreported loci showing associations with the QT interval in the phase 1 study and tested for replication. The red line represents the genome-wide significance level (p = 5 × 10−8). The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2012 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Signal Plot for rs13017846 across an 800 kb Window
Association of individual SNPs in the phase 1 study is plotted as −log10(p) against the chromosomal base-pair positions. The y axis on the right shows the recombination rate estimated from the HapMap CHB and JPT populations. All p values are from the discovery phase. The purple diamond represents the result of the meta-analysis of the phase 1 and 2 studies. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2012 The American Society of Human Genetics Terms and Conditions


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