1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.84
Figure 4 Features of CIDP associated with autoantibodies that target NF155
Figure 4 | Features of CIDP associated with autoantibodies that target NF155. a,b | The reactivity to paranodal antigens (seen here as a yellow signal resulting from the merger of red and green fluoresence) of serum from patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and anti-NF155 antibodies (red fluorescence) is lost in nerve preparations from neurofascin-null mice (part b) compared with those from wild-type mice (part a). Green fluorescence, CASPR1; blue fluorescence, P0 (myelin protein zero). c,d | Septate-like junctions, which link the Schwann cell paranodal loops to the axon, can be seen on sural nerve biopsy samples from seronegative patients with CIDP (part c) but are lost in patients with anti-NF155 antibodies (part d). ml, myelin loop; Nfasc, neurofascin. Reproduced with permission from Elsevier © Vallat, J.-M. et al. Paranodal lesions in chronic inflammatory demyelinating polyneuropathy associated with anti-neurofascin 155 antibodies. Neuromuscul. Disord. 27, 290–293 (2016).
Reproduced with permission from Elsevier © Vallat, J.-M. et al. Paranodal lesions in chronic inflammatory demyelinating
polyneuropathy associated with anti-neurofascin 155 antibodies. Neuromuscul. Disord. 27, 290–293 (2016).
Querol, L. et al. (2017) Autoantibodies in chronic inflammatory neuropathies: diagnostic and therapeutic implications
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