1. Figure 1 Histopathology of low-grade glioma
Figure 1 | Histopathology of low-grade glioma. a–d | Histology of a diffuse astrocytoma that expresses mutant isocitrate dehydrogenase 1 (IDH1 Arg132His) protein, exhibits a loss of expression of ATRX protein (consistent with an ATRX mutation) and exhibits overexpression of p53 protein (consistent with a TP53 mutation). e–i | Histology of an oligodendroglioma that expresses mutant IDH1 Arg132His protein and shows expression of ATRX and a 1p19q codeletion (as shown by fluorescent in situ hybridization (FISH) in parts h–i) FISH probes in part h include one copy of 1p probe (red, targeted to TP73 at 1p36.3), and two copies of 1q probe (green, targeted to ABL2 at 1q25); FISH probes in part i show two copies of 19p probe (green, targeted to locus D19S221 at19p13) and one copy of 19q probe (red, targeted to EDH2 at 19q13).
Buckner, J. et al. (2017) Management of diffuse low-grade gliomas in adults — use of molecular diagnostics
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