1. Shifting Currents in Hyperkalemia Management 2015 in Review

3. Program Goals

4. Hyperkalemia Is a Clinical Challenge

6. ZS-9 Mechanism of Action

7. OPAL-HK Phase 3 Pivotal Study Design

8. OPAL-HK Results Changes in Serum K+

9. OPAL-HK Pre-specified Analysis of Hyperkalemic Patients With HF

10. AMETHYST-DN Change in K+ from Baseline to Week 4

11. PEARL-HF Safety and Efficacy of Patiromer in HF Patients

12. PEARL-HF Study Findings

13. Patiromer Adverse Events*

14. Two Phase, Dose-Ranging Trial of ZS-9 Study Design

15. Two Phase, Dose-Ranging Trial of ZS-9 Findings

16. HARMONIZE Study Design

17. HARMONIZE Study Population Baseline Characteristics

18. HARMONIZE Open Label Phase (48 h) Results

19. HARMONIZE Randomized Withdrawal Phase