Download presentation
Presentation is loading. Please wait.
Published byMariela Hibbs Modified over 9 years ago
1
Highlights of the Day II: SARCOMA “The not so Old and the New” Presented By Dennis Priebat at 2014 ASCO Annual Meeting
2
Sarcoma Highlights: Presented By Dennis Priebat at 2014 ASCO Annual Meeting
3
Long-term Disease Control of Advanced Gastrointestinal Stromal Tumors (GIST) with Imatinib (IM): 10-year Outcomes from SWOG Phase III Intergroup Trial S0033 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
4
S0033 Study Design: Randomized Phase III trial of Imatinib at 400 vs. 800 mg/d for Advanced KIT-expressing GIST Presented By Dennis Priebat at 2014 ASCO Annual Meeting
5
S0033 Long-Term Study Events Presented By Dennis Priebat at 2014 ASCO Annual Meeting
6
Slide 6 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
7
Analysis of On-Study and Post-Progression Therapies (i.e. after progression on imatinib) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
8
Analysis of Post-Progression Therapies (i.e. after progression on imatinib) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
9
Summary S0033: Presented By Dennis Priebat at 2014 ASCO Annual Meeting
10
Summary S0033: Presented By Dennis Priebat at 2014 ASCO Annual Meeting
11
Unmet Treatment Challenges for the Expanding GIST Landscape Presented By Dennis Priebat at 2014 ASCO Annual Meeting
12
AngioTax-Plus trial: a randomized phase II trial assessing the activity of weekly paclitaxel (WP) +/- bevacizumab (B) in advanced angiosarcoma (AS) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
13
Angiosarcoma Presented By Dennis Priebat at 2014 ASCO Annual Meeting
14
Patients & methods Presented By Dennis Priebat at 2014 ASCO Annual Meeting
15
Treatments Presented By Dennis Priebat at 2014 ASCO Annual Meeting
16
Baseline characteristics Presented By Dennis Priebat at 2014 ASCO Annual Meeting
17
Activity - Efficacy endpoints Presented By Dennis Priebat at 2014 ASCO Annual Meeting
18
Grade 3/4 Toxicities Presented By Dennis Priebat at 2014 ASCO Annual Meeting
19
Drug-related SAE Presented By Dennis Priebat at 2014 ASCO Annual Meeting
20
Summary Presented By Dennis Priebat at 2014 ASCO Annual Meeting
21
Proof of Concept Trials for Patients With Advanced Pigmented Villonodular Synovitis(PVNS): Presented By Dennis Priebat at 2014 ASCO Annual Meeting
22
Pigmented Villonodular Synovitis (PVNS) Tenosynovial Giant Cell Tumor (TGCT) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
23
Pigmented Villonodular Synovitis (PVNS) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
24
A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
25
Study Design Presented By Dennis Priebat at 2014 ASCO Annual Meeting
26
Patient Characteristics: Safety Population (n=23) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
27
Duration of Treatment (DOT), April 2014 data cutoff: Median 256 days (range 21-585 days) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
28
Tumor Volume Score (TVS) Presented By Dennis Priebat at 2014 ASCO Annual Meeting
29
PLX3397 Clinical Efficacy in PVNS Rapid and Sustained Tumor Size Reductions in Most Cases Presented By Dennis Priebat at 2014 ASCO Annual Meeting
30
PLX3397 Clinical Efficacy in PVNS Presented By Dennis Priebat at 2014 ASCO Annual Meeting
31
Safety: PVNS Expansion Cohort AEs n = 23 Safety Population Presented By Dennis Priebat at 2014 ASCO Annual Meeting
32
Treatment-Related AEs ≥ Grade 3 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
33
Slide 33 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
34
Slide 34 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
35
Slide 35 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
36
Slide 36 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
37
Slide 37 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
38
Slide 38 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
39
Slide 39 Presented By Dennis Priebat at 2014 ASCO Annual Meeting
40
CSF1R TKI or moAb for PVNS Presented By Dennis Priebat at 2014 ASCO Annual Meeting
41
CSF1R TKI or moAb for PVNS Presented By Dennis Priebat at 2014 ASCO Annual Meeting
42
Take Home Points Presented By Dennis Priebat at 2014 ASCO Annual Meeting
Similar presentations
© 2024 SlidePlayer.com Inc.
All rights reserved.