1. different types of liver cells
Figure 6 Hippo pathway has roles in organ size control and carcinogenesis in
different types of liver cells
Figure 6 | Hippo pathway has roles in organ size control and carcinogenesis in different types of liver cells. Disruption of Hippo signalling by deleting core kinase components (MST1, MST2, SAV1, MOB1A, MOB1B, LATS1, LATS2 and Merlin) leads to uncontrolled proliferation of hepatocytes and bile duct epithelial cells (cholangiocytes). Transgenic mice with deficiency in Hippo pathway show spontaneous liver tumours derived from hepatocytes and/or cholangiocytes, as well as hepatomegaly caused by expansion of hepatocytes. Notably, Sav1-knockout mice exhibit expansion of hepatic progenitor cells, which is not observed in mice with deficiency of other Hippo pathway components. On the other hand, induced ectopic expression of YAP1 converts hepatocytes into progenitor or ductal-like cells. These observations indicate a unique role of SAV1 in regulating YAP1 activities in hepatic progenitor roles. LATS, large tumour suppressor; MOB1, Mob1 homologue protein; MST, mammalian ste20-like kinase; SAV1, salvador family WW domain-containing protein 1; YAP1, Yes-associated protein 1.
Hong, A. W. et al. (2016) The Hippo pathway in intestinal regeneration and disease
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro