1. Figure 3 Histological subtypes of intrahepatic CCA
Figure 3 | Histological subtypes of intrahepatic CCA. a | Bile ductular (mixed)-type intrahepatic cholangiocarcinomas (iCCAs) are composed of areas with small tubular cord-like structures (yellow arrows) with irregular lumina (arrowheads) and cordonal areas expressing hepatocyte markers such as Hep-Par1 (hepatocyte-like areas, yellow arrows). The proportion of each area is largely variable. In general, mucin production is low or absent. Scale bars = 200 μm and 100 μm as indicated. b | Bile duct (mucinous)-type iCCAs are well-to-moderately differentiated adenocarcinoma with abundant stroma (asterisks); these tumour subtypes are composed of tubular, acinar or papillary structures; tumour cells are columnar with abundant clear, eosinophilic or mucinous cytoplasm; mucin production is also present in the glandular lumen (arrowheads). CK7, cytokeratin-7; H&E, haematoxylin and eosin; PAS, periodic acid–Schiff.
Banales, J. M. et al. (2016) Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
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