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Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester  Takeshi Hiramatsu,

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Presentation on theme: "Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester  Takeshi Hiramatsu,"— Presentation transcript:

1 Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester  Takeshi Hiramatsu, MDa, Richard A. Jonas, MDa, Takuya Miura, MDa, Adre duPlessis, MDb, Masahiro Tanji, MDa, Joseph M. Forbess, MDa, David Holtzman, MD, PhDb  The Journal of Thoracic and Cardiovascular Surgery  Volume 112, Issue 3, Pages (September 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 Fig. 1 Mean arterial blood pressures before and after deep hypothermic circulatory arrest in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. The results are the mean ± standard deviation for 10 animals in each group. The labeled time points are Pre (before placement on CPB); NT (normothermia before cooling); HT (after cooling to 15º C); RP15 (15 minutes after beginning the postarrest reperfusion); NT0 (45 minutes after beginning reperfusion when the temperature has reached 36º to 37º C); and NT180 (after 3 hours of normothermic reperfusion). *Difference from controls with a significance of p < 0.05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 Fig. 2 Cerebrovascular resistance (A) and cerebral blood flows (B) before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. The results are the mean ± standard deviation for five animals in each group. Blood flows were measured by labeled microspheres as described in Methods. The time points are described in Fig. 1. *Difference from control animals with a significance value of p < 0.05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 Fig. 2 Cerebrovascular resistance (A) and cerebral blood flows (B) before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. The results are the mean ± standard deviation for five animals in each group. Blood flows were measured by labeled microspheres as described in Methods. The time points are described in Fig. 1. *Difference from control animals with a significance value of p < 0.05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 Fig. 3 The phosphorus 31–nuclear magnetic resonance spectroscopic measurements of cerebral nucleoside triphosphate (A), phosphocreatine (B), and intracellular pH (C) before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. Details of the NMR experiments are described in Methods. The results are the mean ± standard deviation for five animals in each group expressed as a percent of the prehypothermic values (NT). The time points are defined in Fig. 1. *Significance value of p < 0.05, shown only for the designated time points. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 Fig. 3 The phosphorus 31–nuclear magnetic resonance spectroscopic measurements of cerebral nucleoside triphosphate (A), phosphocreatine (B), and intracellular pH (C) before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. Details of the NMR experiments are described in Methods. The results are the mean ± standard deviation for five animals in each group expressed as a percent of the prehypothermic values (NT). The time points are defined in Fig. 1. *Significance value of p < 0.05, shown only for the designated time points. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 Fig. 3 The phosphorus 31–nuclear magnetic resonance spectroscopic measurements of cerebral nucleoside triphosphate (A), phosphocreatine (B), and intracellular pH (C) before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. Details of the NMR experiments are described in Methods. The results are the mean ± standard deviation for five animals in each group expressed as a percent of the prehypothermic values (NT). The time points are defined in Fig. 1. *Significance value of p < 0.05, shown only for the designated time points. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 Fig. 4 Rates of cerebral glucose (A) and oxygen (B) consumptions before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME + ARG) are compared with results in control piglets receiving no treatment. Details of the metabolic rate calculations are given in Methods. The results are the means ± standard deviation for five piglets in each group. The time points are given with Fig. 1. *Significance value of p < 0.05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

9 Fig. 4 Rates of cerebral glucose (A) and oxygen (B) consumptions before and after DHCA in piglets treated with L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME + ARG) are compared with results in control piglets receiving no treatment. Details of the metabolic rate calculations are given in Methods. The results are the means ± standard deviation for five piglets in each group. The time points are given with Fig. 1. *Significance value of p < 0.05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

10 Fig. 5 Cerebral near-infrared spectroscopic measures of oxidation state of cytochrome aa3 in piglets receiving L-NAME, L-arginine (ARG), or L-NAME plus L-arginine (NAME+ARG) are compared with results in untreated control piglets. Details of the measurement techniques are given in Methods. The results are the mean ± standard deviation for five piglets in each group. The time points are given with Fig. 1. *Significance value of p < 0.05. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

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