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Saving the Ends for Last: The Role of Pol μ in DNA End Joining

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Presentation on theme: "Saving the Ends for Last: The Role of Pol μ in DNA End Joining"— Presentation transcript:

1 Saving the Ends for Last: The Role of Pol μ in DNA End Joining
Tanya T. Paull  Molecular Cell  Volume 19, Issue 3, Pages (August 2005) DOI: /j.molcel Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Proposed Structural Preferences of Mammalian Pol X Family Polymerases on Mismatched DNA Ends DNA ends with 3′ overhangs and varying lengths of alignment between the ends are shown as an example. Ends containing extensive homology (A), limited homology of 1 to 2 bp (B), no homology (C), or a single double-stranded end (D) are shown schematically with the proposed polymerase specificities shown at right. The direction of polymerization is indicated with red arrows. Template-dependent synthesis without alignment is suggested to be the activity unique to pol μ; in this case the 3′ overhang sequences are incompatible (see main text). Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2005 Elsevier Inc. Terms and Conditions


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