1. Fig. 1. The effect of dietary micronutrient deficiency on the configuration of a defined human gut microbiota established in gnotobiotic mice.
The effect of dietary micronutrient deficiency on the configuration of a defined human gut microbiota established in gnotobiotic mice. (A) Experimental design. (B) Principal coordinates analysis of pairwise comparisons of fecal microbiota using Bray-Curtis dissimilarities of Wisconsin square root–transformed abundance data obtained from COPRO-Seq analysis. Fecal samples were obtained from mice in the indicated treatment groups at the indicated time points. Gray shaded ellipses and spokes indicate the SEM of sample group centroids from the vitamin A–deficient and the micronutrient-sufficient (monotonous diet control) groups in each experimental phase. PCo 1, principal coordinate 1. (C) COPRO-Seq analysis of the effects of the micronutrient-deficient diets versus micronutrient-sufficient diets on the abundance of B. vulgatus and Bacteroides dorei in the fecal microbiota of gnotobiotic mice. Means ± SEM. **P < 0.01, ***P < [one-way analysis of variance (ANOVA), Tukey’s honest significant difference (HSD), FDR correction; n = 5 mice per treatment group].
Matthew C. Hibberd et al., Sci Transl Med 2017;9:eaal4069
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